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SA node dysfunction or atrial-ventricular (AV) conduction block causes improper heart rate (bradycardia). A new method is described for the statistical analysis of non-random segregation among sibships of different sizes.

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In vitro hematopoietic differentiation of human embryonic stem cells induced by co-culture with human bone marrow stromal cells and low dose cytokines. We have previously shown that amyloid-beta peptide (Abeta) upregulates LGI3 and that Abeta and LGI3 colocalize on plasma membranes of cultured rat astrocytes. Positive CMV-LTT results were shown to be induced by purified inactivated CMV. Lactate dehydrogenase (LDH)1 is the predominant LDH isoform within neurons and unlike LDH5, it preferentially converts lactate to pyruvate which can be used to produce adenosine triphosphate (ATP).

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Revision of the cutoffs for CSIs established in index studies may be required to optimise performance in pragmatic diagnostic test accuracy studies which more closely resemble clinical practice. Good results were obtained also from virus-specific antigens and calibration proteins with molecular weights of somewhat in excess of 50,000 Dalton. The results also suggest the importance of ANA and RF for PSS classification. Study findings call for a global assessment of sleep problems in countries where sleep disturbances represent an insufficiently recognized public health issue.

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Recently, the anticancer properties of Sal-B have received more attention. A cohort of 124 Caucasian patients received a high-dose chemotherapy combination consisting of cyclophosphamide (4-6 g/m2), thiotepa (320-480 mg/m2) and carboplatin (area under the curve 13-20 mg x min/ml) as intravenous infusions over 4 consecutive days. Major thermal injury results in severe prolonged responses with three components: a hypermetabolic response, inflammatory responses, and endogenous wound-healing processes. It is unclear whether this pattern is unique to people with chronic schizophrenia, or if it occurs in individuals after a first episode of psychosis (FE), or when at clinical high-risk for psychosis (CHR).

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79 astrocytic tumors classified according to the WHO classification and stained with a modified AgNOR staining technique were analysed with the help of an automatic image analysing system. Prolonged Rhinovirus Shedding in a Patient with Hodgkin Disease. Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy. Peptide YY (PYY) and ghrelin are gastrointestinal tract-derived hormones that play roles in the regulation of food intake and energy balance. The study population included 33 pediatric NF1 patients (20 males and 13 females).

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To investigate the clinical impact of MRI based cervix cancer brachytherapy combined with external beam radiochemotherapy applying dose volume adaptation and dose escalation in a consecutive group of patients with locally advanced cervix cancer. Effects of Carthamus tinctorius injection on bcl-2, caspase-3 expression related to neurons apoptosis after local cerebral ischemia Molecular Characterization and Expression Analysis of P38 MAPK Gene and Protein in Aquatic Midge, Chironomus riparius (Diptera: Chironomidae), Exposed to Environmental Contaminants. Unsuspected central neck nodal metastases in cN0 PTC patients are associated with increased RAI utilization, but no survival difference. Adults with autism were impaired on the posed/genuine smile task and looked at the eyes significantly less than did controls.

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In this multi-method study, the authors examined student learning outcomes, perceptions, employment choice and retention following implementation of a new capstone nursing course. Spectacular images of the process of myosin II filament formation and organization in migrating cells are unveiled by super-resolution imaging. However, in the backward uncertainty propagation, one moves in the reverse direction, from the distribution function towards the parameter subspace.

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Minimal T-cell requirements for triggering haemophagocytosis associated with Epstein-Barr virus-driven B-cell proliferation: a clinical case study. Results showed that brain proteolipid protein synthesis was greatly depressed, indicating that undernourishment limited the production of myelin components.

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Growth of ethylnitrosourea-treated cells in TPA-substituted medium increased the transformation frequency 8-fold. The CCFNI-P is valid for investigating the needs of Iranians who have a family member hospitalized in an ICU. Automatic detection of the anterior and posterior commissures on MRI scans using regression forests. We describe a simple protocol to evaluate the responsiveness of hypocotyls to commercial BRs and/or BR inhibitors under a range of light conditions. These results demonstrate the utility of the zebrafish embryonic model for the study of tumor cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions.

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The method is also suitable for determining the xanthine content of beverages by direct injection of diluted samples. Cell wall turnover in batch and chemostat cultures of Bacillus subtilis. Lower initial CBF at presentation is a risk factor for developing CV with infarction.

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Evidence against presynaptic alpha-adrenoreceptor modulation of cardiac sympathetic transmission. The tongue can substitute human sensory systems and has been used as a medium of input to help impaired patients communicate with the world. Using the two-hybrid screen, we identified atrophin 1-interacting protein 4 (AIP4) as an E3 ubiquitin ligase that specifically targets Smad7 for ubiquitin-dependent degradation without affecting the turnover of the activated TbetaRI. The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.

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High P-T Raman measurements of solid and fluid hydrogen to above 1100 K at 70 GPa and to above 650 K in 150 GPa range, conditions previously inaccessible by static compression experiments, provide new insight into the behavior of the material under extreme conditions. However, due to ongoing demographic change, the main target group of mobile devices will be older users. The population encompassed a convenience sampling of patients presenting with STI symptoms. We present three cases in which an RCA with an anomalous origin from the left sinus was corrected with coronary artery bypass grafting with the assistance of intraoperative Doppler flow measurements to guide the decision to preserve the proximal anomalous native vessel.

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Several questions concerning ketoconazole-induced hepatic injury remain unanswered, including (1) does ketoconazole alter cytochrome P450 expression at the transcriptional level?, (2) what types of gene products responsible for cytotoxicity are induced by ketoconazole?, and (3) what role do the major metabolites of ketoconazole play in this pathophysiologic process? Targeting of the JAK-STAT pathway has been the intense focus of therapeutic development and led to the approval of the JAK1/2 inhibitor, ruxolitinib. Diagnostic and therapeutic role of endoscopic retrograde cholangiopancreatography in biliary rhabdomyosarcoma.

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The facial-submental artery island flap can reliably be used for reconstruction of the lower and middle thirds of the medium-sized oral and maxillofacial defects and the reverse pattern for reconstruction of the middle and upper thirds of the medium-sized oral and maxillofacial defects. During late phase of DNA damage, a remarkable reduction of NFBD1 was observed in dying but not in surviving A549 cells bearing wild-type p53. Transverse myelitis associated with Mycoplasma pneumoniae infection. Spatially resolved fluorescence lifetime mapping of enzyme kinetics in living cells. The samples harvested in the spring contained higher contents of chlorogenic acid than those collected in other seasons.

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Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific. Femtosecond laser spectroscopy of the rhodopsin photochromic reaction: a concept for ultrafast optical molecular switch creation (ultrafast reversible photoreaction of rhodopsin). Midazolam (5 mg) or fentanyl (0.1 mg) was given orally from a small bottle with a small orifice 30 min before transfer to the preoperative holding room. Factors associated with acute diarrhoea in children in Dhahira, Oman: a hospital-based study.

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High-yield synthesis of wax esters catalysed by modified Candida rugosa lipase. Simulation results show that DCM competes with previously proposed surface Laplacians and with the model based Minimum Norm Estimates (MNE) computed with a Boundary Element Model (BEM). Software frameworks in MLSG are extensively employed to analyze hundreds of thousands of multi-omics data by high-throughput technologies. We report on a four-year-old amaurotic child with catastrophic epilepsy due to bilateral occipital cortical dysplasia.

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The molecular basis of BLAD is a single point mutation (adenine to guanine) at position 383 of the CD18 gene, which caused an aspartic acid to glycine substitution at amino acid 128 (D128G) in the adhesion molecule CD18. However, the effects of oncolytic virus-infected carrier cells in human oral squamous cell carcinoma (OSCC) have not yet been examined. A variety of methods were used to address the unique features of IMPDH1 in the retina, including Northern blot analysis, serial analysis of gene expression (SAGE), immunohistochemistry, transcript sequencing, and Western blot analysis.

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Prostatic biopsy after irradiation therapy for prostatic cancer. Essentially, GLUT3 and also to some extent GLUT1 was present in maternal leukocytes and platelets.

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Fish from two of the reservoirs supplying Tehran with potable water contained moderate levels of DDT. In this way the thresholds are permanently modified in the integrating structures of the system. Preoperative estimated glomerular filtration rate was calculated using Cockcroft-Gault formula. From the changes of P parallel and P perpendicular measured during stretching it was concluded the polytene chromosome bands have three, at least, DNA packing levels, tentatively described as 100 A fiber, 250 A coil and chromomere.

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Tolerance to the antinociceptive effect of 7-hydroxymitragynine developed as occurs to morphine. Short sleep duration preferentially increases abdominal adiposity in adults: preliminary evidence. Results of arterial blood gas analysis can be biased by pre-analytical factors, such as time to analysis, syringe type, and temperature during storage. During the carcinogenesis process, the mast cell population is comprised of two distinct subpopulations that appeared simultaneously in the same tissue, i.e. Some comparisons of mean responses for selected individual items are also presented.

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We report a case of an anorexic adolescent presenting to the emergency room with acute onset of chest pain due to spontaneous pneumomediastinum. It is based on aorta lumen segmentation and graph matching method. Modification of visible spontaneous emission with silicon nitride photonic crystal nanocavities.

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Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats. In this study we have explored a novel approach to altering Ad type 5 (Ad5) vector targeting based on serotypic differences in fiber function. Diazepam has proved successful which accounts for its widespread use in Great Britain and developing countries. Structural analysis of the O-antigen polysaccharide from Escherichia coli O152.

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There was also no increase in secretion of dense granule content, in contrast to studies using rottlerin where secretion was enhanced. Recent studies of pDC have revealed them to be crucial mediators linking the innate and adaptive arms of the immune system. This case illustrates the importance of careful history taking and of early recognition of extraintestinal manifestations of IBD in order to appropriately target treatment and prevent unnecessary morbidity. The scalp topography of human somatosensory and auditory evoked potentials. Level 3 evidence involved consensus statements from experts or descriptive studies.

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The survival difference among the three groups was statistically significant. Confocal images of the excised tumor showed extensive co-localization of liposomes and macrophages in both cases. In this study, the effect of V2O5 on mitosis, sister-chromatid exchange (SCE), micronucleus formation (MN), and gene mutation in Chinese hamster V79 cells was determined.

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Pelvic autonomic cells exist not only in nerve components but also along viscera. The GPs interpreted the ECGs themselves and initiated prehospital thrombolysis according to a set of criteria. In a retrospective study 40 ICU patients, all underwent Continuous Arteriovenous Hemofiltration (CAVH) for acute pulmonary, acute renal insufficiency or both, were evaluated for lung function parameters and fluid balance. Issues of nephrotoxicity and immunocompetence after infusion remain to be defined.

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We present an interesting case of spinal cord compression with craniovertebral instability in an 18-month-old female requiring circumferential cervical spine and craniovertebral stabilization. The one-dimensional preferential growth is explained in terms of the crystallographic features of InOOH. Its salient clinical features include presence of syndesmophytes at the thoracic or thoraco-lumbar spine, mild sacroiliitis, calcification at the acetabular margin of hip, preserved bone density, equal distribution in both sexes and lack of HLA-B27 association.

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The objective was to measure change in iron status in Moroccan children who consumed their habitual diet containing low amounts of bioavailable iron. However, the optimum ratio that will separate populations with high from low cardiovascular risk remains controversial.

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Controversy exists regarding the optimal strategy to minimize recurrent ulcer hemorrhage after successful endoscopic hemostasis. Chewing movements were measured by time (sec), number of cycles, and a time/cycle ratio. The DNA damage response molecule MCPH1 in brain development and beyond.

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Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. A total of 200 non-syndromic CHDs patients and 202 normal control patients were sampled. Polymer-supported triazenes as smart reagents for the alkylation of carboxylic acids.

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This paper presents a critical review of the national reproductive health policies and programmes of Turkey and discusses the influence of national and international stakeholders and donors on policy and implementation. Medullary carcinoma should be considered in the differential diagnosis of unusual thyroid carcinomas with predominance of cells with oncocytic changes. The UFSBD is presently engaged in a vast evaluation programme which will extend over six years.

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A large mesenteric tumour in a Rusa hind (Cervus tiomoriensis) was diagnosed as a leiomyosarcoma on the basis of tumour size, degree of necrosis, cellular pleomorphism, anaplasia, mitotic activity and evidence of local invasion. Mean values of FMD were examined across categories of occupation, work hours, and the other exposures using regression analyses. This paper gives a brief review on HLos cardioprotective effects based on recent research progress. Their methods, it is shown, were shared with contemporaries seeking to generate and manage other troves of evidence and in fact reflect a complex ecosystem of imitation and exchange across fields of inquiry.

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Progression of the optic disk as a reference standard in glaucoma. Genetic differences between C57BL/6 and DBA/2 mice in the inductions of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol, and bilirubin by 3-methylcholanthrene. lactis conferred an 800-fold increase in survival after 1 h exposure to 4 mM hydrogen peroxide, and a 160-fold greater survival in long-term (3 days) survival of aerated cultures in a cydA mutant, which is unable to respire. Clinical experience to date suggests that this topical antihistamine is at least as effective as other current first-line therapeutic approaches for the treatment of this condition, including oral H(1)-receptor antagonists and sodium cromoglycate. The vasoactive-related peptide systems and AA cascade-related enzymes may mediate placental development and fetal membrane detachment after parturition in cattle.

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This analysis confirms that the Westran pig is highly inbred and we propose that analysis of chromosomally dispersed highly polymorphic markers is an accurate and reproducible method for assessing the level of inbreeding of a pig herd. The findings indicate that an increase in player load during AFL preseason match play resulted in compromised postmatch mucosal immunological function. Custom built bite-block endotracheal tube holder for prolonged intubation. However, the influence exercised by the different types of waste water and their potential nutritive substances varies. Anabolic effects of PTH in cyclooxygenase-2 knockout osteoblasts in vitro.

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Integral to the successful use of the pulmonary artery catheter is to accurately obtain and interpret invasive pressure monitoring data. Phase II trial of paclitaxel shows antitumor activity in patients with previously treated germ cell tumors. In general, the average kinetic chain length increased with conversion until the onset of autodeceleration, when the kinetic chains decreased in length as the propagation reaction became diffusion-controlled.

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Clinical features commonly observed in the fibular hemimelia such as knee valgus, knee instability, tibial bowing, ball and socket ankle, ankle instability, tarsal coalition, leg length inequality were compared between both groups. Recurrent embolic strokes associated with persistent left superior vena cava draining into the left atrium All IgG-CIC-positive serum samples from CF patients were found to contain antibodies against Pseudomonas aeruginosa in the isolated complexes.

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A model for trimeric allophyocyanin is presented in which the appearance of the 650-nm absorption band is induced by a particular kind of chromophore-chromophore interaction. The growth rate is the decisive factor in the transition of the cells to the persister state. A total of 207 eligible and consenting women were given mifepristone (200 mg oral) and the option of taking 400 microg misoprostol either orally or sublingually two days later, with the option of home-use. Plastic surgery options for the treatment of chronic foot ulcers

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The monoclonal antibody 3H8 also reacted with fibrinogen in Western blots and in ELISA tests. The virus specificity of human in vitro cytotoxic T cell responses to influenza virus was studied with the use of peripheral blood mononuclear leukocytes from normal adult volunteers. Questions are raised about the functional significance of these surface proteins. The contributions of TE and TM modes to the angular emission power will be analyzed for the grating optimization, which have not been expressed in detail. Preoperative and postoperative nocturnal polysomnogram data were paired and analyzed statistically.

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A self-report survey was sent to physician members of the Canadian Association of Gastroenterology, with a second mailing three months later to increase response rate. LPS injection induced macrophage infiltration and cellular proliferation in the mesangium together with fibrin deposition and monocyte chemoattractant protein 1 mRNA expression, as well as antigen deposition of tissue factor, factor V, factor X, and protease-activated receptor 2. Prevalence and clinical findings of biopsy-proven glomerulonephritidis in Iran.

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The pyrrolidine ring of nicotine is derived from the diamine putrescine, which can be synthesized either directly from ornithine via the action of ODC, or from arginine via a three enzymatic step process, initiated by ADC. Characterization of the asialoglycoprotein receptor in a continuous hepatoma line.

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In conclusion, the apparent kinetic parameters in transcellular permeability assays depend on passive permeability and efflux pump activity. Thus, we determined the effect of HRAS oncogene expression on cell proliferation in a cell line immortalized by E6 and E7 oncogenes.

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Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. This paper describes the first in the world experience with the treatment provided in 1990 to a female patient suffering from hypereldosteronism associated with adenoma of the left adrenal. In contrast, at high temperature there is no similar statistical description of the spectrum.