Warafin is an anticoagulant medication that is highly effective at preventing clotting disorders but which has a narrow therapeutic window. If Warafin is under effective patients are at risk of stroke, if it is over effective patients are at risk of bleeding complications. Physicians routinely and regularly measure a blood test (called the "INR") that determines the effectiveness of Warafin and have a range of test values (the "therapeutic range") in which they try to keep the patient. By convention Warafin is taken at dinnertime, however this is the same time of day that highly variable consumption of dietary vitamin K occurs (found largely in green leafy vegetables) and vitamin K alters the effectiveness of Warafin. Given vitamin K has a very short half-life (i.e. it is only active for a short period of time after it is ingested) it may make more sense to take Warafin in the morning (when very little vitamin K is ingested) to produce a more consistent drug effect. The purpose of this study is to determine whether switching current Warafin users from evening to morning dosing decreases time spent outside the therapeutic INR range.
Other names for this medication:
Warfarin,
Coumadin,
Aldocumar,
Circuvit,
Coumadine,
Hemeran,
Jantoven,
Kovar,
Marevan,
Marivarin,
Martefarin,
Orfarin,
Panwarfin,
Simarc,
Warafin,
Warfarina,
Warfarine,
Warfin,
Warin,
Warlin,
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