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Inherited hemolytic anemia due to pyruvate kinase (PK) deficiency is an autosomal recessive disease of the Basenji dog that closely resembles human PK deficiency. Fusang: The Enlightenment Story of the Chinese Discovery of America.

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Survival after palliative radiotherapy in geriatric cancer patients. A serious advantage of this technique is its quickest realization allowing to obtain histological serial sections of the cochlea in 6 or 8 weeks.

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The species specific nature of an antigenic determinant previously discovered in the scrapie form of prion protein (PrPD) from cattle, sheep and mice, was further investigated in normal prion protein (PrPC) from these and other species. Our study may thus contribute to the elucidation of the precise molecular and cellular events that eventually render traumatic spinal cord tissue non-permissive for regeneration.

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Twenty-two per cent of all respondents were not comfortable discussing assisted suicide with patients. In this study population, the mean pressure in the middle ear showed significant variation only during the Valsalva maneuver at the first time point evaluated in the three groups of ears. A comparative trial of flunisolide and sodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis. Medication prescribing in this growing population is especially difficult. Synthesis of novel 2,5-disubstituted 1,3,4-thiadiazoles for their potential anticonvulsant activity: pharmacophoric model studies.

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However, the understanding of how to deliver those interventions in diverse settings is limited. Application of 19F NMR spectroscopy to a study of carbon monoxide binding to human hemoglobin modified at Cys-beta 93 with the S-trifluoroethyl residue. This study also demonstrated the presence of p190 transcript in nine out of 13 study patients.

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The purpose of this study was to investigate the test-retest reliability and concurrent validity of the Flemish Physical Activity Computerized Questionnaire (FPACQ) in employed/unemployed and retired people. For EM, combined staining by EHCS on 30 microgram tissue sections followed by IHCS for prolactin on ultrathin Epon sections (enzyme-labelled antibody method) provided acceptable results. Facile Fabrication of MoS2-Modified SnO2 Hybrid Nanocomposite for Ultrasensitive Humidity Sensing.

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Whereas the role of ANG II in renovascular and glomerular development has received much attention, little is known about the potential role of ANG II and its receptors in the morphogenesis of the collecting system. Different species of Laupala sing distinctively and show species-specific acoustic preferences. A novel, antimicrobially active analog of gramicidin S without amphiphilic conformation. Drug-induced neuroadaptations within the nucleus accumbens, including activation of cAMP-dependent protein kinase A (PKA), may contribute to the synaptic plasticity and behavioural changes that underlie drug addiction. Anodic electrochemiluminescence (ECL) of CdSe quantum dots (QDs) in a neutral system was for the first time observed at a relatively low potential by using sulfite as a co-reactant to produce the ECL emission at an indium tin oxide (ITO) electrode, which could be used for the sensitive detection of ECL quenchers using dopamine (DA) as a model molecule.

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The reduction of thyrotoxicosis is rarely obtained (2 cases), mainly because on the one hand, correct plasma lithium level (0.7-1.2 mEq/L) is rarely obtained (3 cases only), on the other hand because a high dose of lithium is required, perhaps owing to high clearance of lithium in thyrotoxicosis. Hence a diagnosis of spinal arterio-venous malformation was entertained.

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Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures. 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), a natural agonist of the peroxisome proliferator-activated receptor gamma (PPARgamma), is found recently to be able to function in the regulation of Smad2 activity. GM increases were detected in left insula, superior temporal gyrus, and putamen nucleus, and right supramarginal gyrus.

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Benign preoperative surgical indications included pelvic mass, family history of cancer, hyperplasia without atypia, prolapse, endometriosis, pelvic pain, abnormal uterine bleeding, or leiomyomas. These measures of training-induced neural plasticity were graded from distal to proximal in the upper limb. Polarized and isotropic spectra of a highly oriented HDPE cylindrical rod and an isotropic HDPE sample have been compared. Furthermore, the hpRNA transgene was expressed in the highly resistant transgenic lines, giving rise to abundant levels of 21-24 nt small interfering RNA (siRNA). It also underlines the need for studying this important facet of plant-fungal interactions in depth which may in future help to fetch more advantages and to avoid the severe consequences in agriculture and other related fields.

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The sampling using the triplets ordering turns out to be superior to both other approaches. Muscular imbalances in high performance swimmers: damage to the locomotor system The purpose of the study was to determine the effects of aprotinin on (1) renal function, (2) apoptosis and apoptotic signaling, and (3) the inflammatory response of the kidney after ischemia-reperfusion injury.

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Electronic transport through molecular junctions with nonrigid molecule-leads coupling. For comparison, premade iron oxide nanoparticles, attached to gold nanorods by electrostatic interactions, were also studied.

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Prescribing second-generation antipsychotics and the evolving standard of care in Italy. Maternal blood loss by expansion of uterine incision at caesarean section--a comparison between sharp and blunt techniques. The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-kappaB) inhibitors, but not by mitogen-activated protein kinase (MAPK) inhibitors. Increases in FGF-2 expression could be stimulated by other factors known to increase reactive oxygen species (ROS) signaling in PASMC (endothelin-1 and transforming growth factor-beta1), whereas antioxidants attenuated these increases. We report the case of a 9-year-old boy who presented with a small bowel obstruction caused by torsion of a large mesenteric lipoma.

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It is still elusive why certain self proteins induce an autoimmune response. A hospital infection control program, consisting of an infectious disease control officer, written protocols, and staff training, is critical to reducing HAIs and promoting patient, staff, and client health. As structural information becomes available for a wider variety of systems, the questions about mimicry will be more effectively addressed.

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The Scottish Centre for Infection and Environmental Health (SCIEH). During running turns, both humans and ostriches control body rotation by generating fore-aft forces. To develop the Dutch Multifactor Fatigue Scale (DMFS), a new scale to assess the nature and impact of fatigue and coping with fatigue in the chronic phase after acquired brain injury (ABI) and to analyze the psychometric properties of this scale in a mixed group of patients with ABI. Considering that recovery is a stressful and challenging experience, the transactional stress-coping theory appears relevant to explore the appraisal and coping processes involved in recovery.

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Ectopic expression of YY1 inhibits, while knockdown of endogenous YY1 enhances, TGF-beta- and BMP-induced cell differentiation. This variability is a challenge to anatomists to attempt to relate size differences to differences in characteristic behaviour.

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Participants were 1278 families from the Gemini twin cohort, using data from one child per family selected at random to avoid clustering effects. Positive staining with anti-SAA antisera was localized to the cytoplasm of cells scattered within the mesenchymal stroma, thought to be fibroblasts, and to foetal stem vessel endothelium and some individual fibrillar structures in villous stroma and perivascular tissue. DICOM images of the fistula, obtained from the angio-computed tomography, were a source of the data applied to develop a 3D geometrical model of the fistula. The removal behaviors can be explained by a selective aggregation of heavy metal carriers present in CSO and a specific interaction between hydrolyzed coagulant species and soluble metals.

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The aim of this paper is to report on our surgical strategy and technique and to identify the best management for intracranial dermoids and epidermoids tumors (IDETs). Interleukin 10 and transforming growth factor beta contribute to the development of experimentally induced allergic conjunctivitis in mice during the effector phase. The sentinel node concept has become one of the most interesting topics in the treatment of head and neck cancer. The characteristics and functions of microbial IgA proteases are reviewed.

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Endothelins 1 and 3 and big endothelin-1 contract isolated human placental veins. The current study used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of numeracy and the influence of age on these correlates with a group of adults and a group of third graders who had average to above average mathematical ability. Nested case-control study on the risk factors of colorectal cancer.

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Necrosis of muscle, nerve and skin tissue may result owing to oxygen deprivation. Balance sheets were constructed for three systems: animal production, crop production, and the agricultural sector as a whole. Early correction of developing class III malocclusions remains a complex challenge. Cotreatment with calcitriol enhanced both modes of TNFalpha-induced death in MCF-7 breast cancer cells.

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Ossification of the ligamentum flavum of the lumbosacral spine in the Polish hospitalized population - a prospective cohort study. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. To determine whether retention of the native patella during total knee arthroplasty is appropriate in patients with rheumatoid arthritis.

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In this article, we propose a possible protein concentration mechanism of this detergent-assisted foam fractionation: A detergent binds to an oppositely charged protein, followed by the detergent-protein complex being adsorbed onto a bubble during aeration. Following intracerebral injection of(14)C-phosphatidylethanolamine and(3)H-chimyl alcohol into 18 day old rats, the ethanolamine phosphoglycerides were isolated and analyzed. Twenty-two patients with primary lymphoma arising in mucosa-associated lymphoid tissue of the nasopharynx have been studied with reference to age, sex, clinical symptoms, laboratory finding, radiological finding, histological subtype, and immunohistochemistry. Residual MMA of 120 resin specimens were measured using high-performance liquid chromatography.

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The present study was performed to investigate the differences in tactile sense recognition between mood disorder patients and control subjects using a tactile sense recognition P300 measuring system. The results indicate that mating is a biological stimulus for the release of endogenous opoids, possibly to (a) prevent intense sexual stimulation from becoming aversive, and (b) increase its reward value. Updating neovascular AMD treatment guidelines to reflect the evidence base for ranibizumab as a preferred first-line therapy would be beneficial for physicians in making informed treatment choices and ultimately helping to ensure the best care for patients. Haematologic alterations included thrombocytopenia and stomatocytes.

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Today, the indication to tracheotomise a child is generally ruled by the anticipation of long-term (cardio)respiratory compromise due to chronic ventilatory or, more rarely, cardiac insufficiency, or by the presence of a fixed upper airway obstruction that is unlikely to resolve for a significant period of time. Evidence is presented that low serum thyroxine-binding globulin (TBG) levels in Aborigines are widely distributed throughout Australia, and that these are inherited rather than acquired. Arrhythmia mechanism post total cavopulmonary connection is highly varied, encompassing simple and more complex substrates, documentation of which facilitates a strategic approach to invasive arrhythmia management. A broad spectrum of ocular anomalies is associated with Alagille syndrome. We could not demonstrate significant changes in bladder pressures on cystometry either during filling or voiding.

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These findings were confirmed by direct measurement of the partition of radiolabeled halothane into the membranes and by direct determination of the partition parameter of 5-doxyl decane by electron paramagnetic resonance spectroscopy. Observed weight and height distributions were compared with national averages and found to be highly aberrant in older women.

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Polyclonal antiserum to the proteins was produced in mice and used to confirm the reduction in their retrograde transport in sciatic nerve of diabetic and acrylamide-treated rats. A modest correlation between abnormal platelet response during treatment with ASA and the presence of unstable plaques suggests that these two phenomena may coexist but we were unable to show a clear association between them. Better cleansing and willingness to retake the regimen was achieved with the oral sodium phosphates solutions than with polyethylene glycol plus bisacodyl. The concentration of high density lipoprotein was markedly reduced, although the proportion of high density lipoprotein 1 was substantially elevated when compared to normal subjects. The gene chip technology was used to analyze and detect the miRNAs differentially expressed in tissues and cancer cells.

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ETEC strains isolated from humans may produce a heat-labile enterotoxin (LT) and two types of the heat-stable enterotoxin STa, called STh and STp, encoded by the estA gene. In the cirrhotic liver, gene expression of the multifunctional cytokine oncostatin M (OSM) is up-regulated, but its cellular origin is unknown. While fruit quality in black elder (Sambucus nigra) is unrelated to fruit color, it is indicated by alternative pedicel phenotypes. Structural organization of the human neuronal nitric oxide synthase gene (NOS1). Differences in the expression of histocompatibility antigens on mouse lymphocytes and tumor cells: immunochemical studies.

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The results demonstrate that these polyclonal antisera also recognize epitopes shared with other proteins synthesized in culture by skin fibroblasts. The authors, with the aid of the literature, recall the characteristic physical findings, the clues of the diagnosis and the modalities of the surgical treatment of such lesions. Analysis of the seasonality of LN may contribute to the understanding of the pathogenesis of LN, which may be multifactorial, as the different classes of LN represent different types of glomerular injury. The barriers described by women are not insurmountable but needed to be integrated in a global comprehensive health policy.

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Harmonic Motion Microwave Doppler Imaging method for breast tumor detection. A rat model was designed to allow prolonged direct observation of leukocyte-venular endothelial adhesion in a femorodistal bypass simulation. Linguistic and other psychological aspects of paroxysmal aphasia.