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Therefore, the ion transport phenotype of human bronchial epithelial cells exposed to cigarette smoke extract is similar to that of cystic fibrosis epithelia in which there is sodium absorption out of proportion to chloride secretion in the setting of increased mucus secretion. Exome QTL-seq broadens the utility of NGS-based gene/QTL mapping in organisms with large genomes. Our objective was to investigate which MMPs were constitutively expressed in breast tumor cells versus those that could be up-regulated by a number of agents known to affect MMP expression in other cell systems.

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Vulnerable plaques were mostly of Type IV category of AHA classification and of thin cap fibroatheroma type by modified American heart association classification. These results indicate that an appropriate PTEN activity, probably regulated by its differential localization, is necessary for coordinating cell proliferation and early morphogenesis.

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Furthermore, gene expression analysis was performed in a subset of 32 of these tumors, and findings were integrated with array-CGH data. We hypothesized that the double reconstruction would provide better control of anterior laxity in both flexion and extension. Evaluated were the effects of a training program for developing communication skills of health professionals (physicians, physiotherapists, and nurses) along with a reorganization of patient information schemes.

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This hydrolysis implicates lower results in the estimation of the desialylated glycoprotein by electroimmunodiffusion. The inhibitory effect of Cactus polysaccharides on lung squamous carcinoma cells were detected by MTT assay. whipplei can be evaluated by means of gene complementation techniques.

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It is proposed that fibronectin and tenascin may contribute differently to tissue repair in the trachea by interfering with cell proliferation of epithelial cells and fibroblasts. Parapharyngeal and retropharyngeal infections, which can potentially cause life-threatening complications, could be treated conservatively with no need for surgical drainage. Surgical margins and depth of excision need to be standardized to help dermatologists manage disease. Future investigators of surgical RCTs should make an effort to comply with the CONSORT checklist.

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Ultraviolet radiation-induced apoptosis in keratinocytes: on the role of cytosolic factors. Over a period of 18 months, 20 patients were operated on for various brainstem and/or cerebellar lesions. Both paclitaxel and vinblastine cause a redistribution of RIIalpha within the cell. Arguments are presented in favor of the interpretation that each variant nucleotide is the third nucleotide of the codon containing it, and that none of the four differences would result in a difference in the respective amino acid translated.

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This is perhaps related to the antidopaminergic effect of cyproheptadine. Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells. These observations suggest that there are two acid phosphatases in ameloblasts. Patients completed neurocognitive assessments and social cognition tasks.

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Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice. In recent years, the use of virtual prototyping has increased in product development processes, especially in the assessment of complex systems targeted at end-users. Assessing allocation concealment and blinding in randomised controlled trials: why bother? By Northern blot analysis of RNA isolated from phototrophically grown cells a transcript of 0.95 kb was detected which is the expected length for a mRNA encoding both genes.

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In chronic experiments on waking rabbits, the foci of heightened excitability in the sensorimotor cortex and mesencephalic reticular formation affected in a similar way the background neuronal activity in the superior colliculi and that evoked by light stimuli. Serum concentrations of adiponectin, leptin and soluble leptin receptor were determined by enzyme-link immunosorbent assay and the free leptin index was calculated as the ratio of serum leptin to soluble leptin receptor for each sample.

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Uncomplicated repair has a minimal risk of neurological injury and a low risk of renal failure requiring dialysis in patients without preoperative renal dysfunction or renal artery stenosis. Our study, although small, showed that the resistance exercise group had significantly better function, as measured by total ALS Functional Rating Scale and upper and lower extremity subscale scores, and quality of life without adverse effects as compared with subjects receiving usual care. Diffraction intensities measured while varying the D(2)O/H(2)O ratio in the humidity was used to solve the phase problem. Our results demonstrate that MeHg levels in rice paddy soil were a function of both methylation and demethylation processes and the net methylation potential in the rice paddy soil reflected the measured MeHg production at any time point.

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If this, so-called, washin-washout effect is substantial it may interfere with the diagnosis, as a major part of breath HCN may originate from the respiratory tract, due to recent exposure, and not from systemic exposure. Observations of quality of life (QOL), morbidity, and mortality were obtained from the results of a prospective phase II study of intermittent androgen suppression for recurrent prostate cancer after radiation therapy. We introduce a web-based library (http://www.psy.vu.nl/mxbib) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests.

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Angiotensin I conversion by the microcirculation of the nonhuman primate. Vaginal delivery within 24 h was common, with less morbidity than cesarean delivery, in this nulliparous group presenting with severe preeclampsia and an unfavorable cervix.

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Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis. The present study used data from a national survey of women in TOPS (a weight reduction organization) in 1969. The RAS proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation.

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Results were analysed with regard to different tumour groups, according to academic and non academic hospitals, and correlated with epidemiological data on cancer incidence. Second-order Type I and Type II plaids were constructed by combining two orientation-filtered random-dot gratings.

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As the condition generally occurs in exposed areas of the body, genital myiasis is a rare condition, and myiasis of the uterine cavity is even rarer, only one case having been previously described in the literature. Alignment quality is assessed with a battery of metrics including tensor overlap, fractional anisotropy, inverse consistency and closeness to synthetic warps. Hypertensive adults are more susceptible to noise exposure with a greater effect on ambulatory SBP. The MET/HGF likely is functional and may be activated in autocrine fashion in vivo. Acidified 2,2-dimethoxypropane (DMP) has been used as a rapid chemical dehydrating agent en route to plastic embedding and ulthrathin sectioning for conventional electron miscroscopy (J Histochem Cytochem 23:107, 1975).

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The enlargement consisted in HMLNMs in 26 (15 men, 11 women), with a mean age of 57.6 (range 19-78) years. Capillary permeability to interstitial microinjections of macromolecules and influence of capillary hydrostatic pressure on endothelial ultrastructure. Healthcare workers (HCWs) were at the frontline during the battle against Severe Acute Respiratory Syndrome (SARS). Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine with potential atherogenic properties whose role in human obesity has been recently suggested.

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Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. Among others, we have identified a strong up-regulation of a cluster of genes involved in cholesterol metabolism including apolipoproteins (apoC-I, apoC-II, apoC-IV, apoE), the scavenger receptor CD36, steroid-27-hydroxylase (CYP27A1), liver X receptor alpha (LXRalpha), and ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1). The use of performance reference compounds thus avoids the need for extensive re-calibration when the sampler body geometry is modified. On the use of a dynamic approach to the estimation of dissociation constants for reversible competitive antagonists.

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Antitumor efficiency of combined therapy of experimental tumors with diazan and antibiotics was studied. Differentiation between human immunodeficiency virus type 1 (HIV-1) and HIV-2 isolates by nonradioisotopic reverse transcriptase-typing assay. Studies on the role of lymphocyte-activating factor (Interleukin 1) in antigen-induced lymph node lymphocyte proliferation.

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The results of a questionnaire on how 131 family doctors in Glasgow and the West of Scotland obtain information regarding recent advances in rheumatology are described. Serum CA-125 is of value in differential diagnosis of benign and malignant adnexal masses, especially in postmenopausal women.

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aeruginosa has three azoreductase genes, paAzoR1, paAzoR2 and paAzoR3, which as recombinant enzymes have been shown to have different substrate specificities. Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: population based cohort study.

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Methyl bromide and heat treatments did greatly reduce spore viability in the boards, but did not reduce chalkbrood levels in the field. Remnants of the male sperm pumps as well as giant, inflated female sperm receptacles evidence that, despite high costs, reproduction with giant sperm can be an evolutionary successful strategy. To further probe the role of Epac1 in Akt protein kinase activation and cellular proliferation, we employed the cAMP analog 8-CPT-2-O-Me-cAMP, which selectively binds to Epac1 and triggers Epac1 signaling.

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Two-stage hepatectomy combined with converting chemotherapy achieved a successful treatment for initially unresectable multiple bilobar colorectal liver metastases However, real-time acquisition speed is performed at the cost of decreasing spatial resolution, leading to echocardiographic data with poor definition of anatomical structures and high levels of speckle noise.

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The experiments assessed the development of plants (root number and length), changes in key enzymes in plant defense (polyphenol oxidase and peroxidase) and induction of secondary compounds(total phenolic and quercetinic flavonoid fraction). Complications of peroperative hypotonia in combined trabeculectomy-cataract operations

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Podoplanin, a transmembrane glycoprotein, has been considered to be expressed specifically by lymphatic endothelial cells. With iron-supplemented microsomes from rat liver, the compounds formed were qualitatively and quantitatively the same as with soybean lipoxygenase, whereas with 18,000 X g rat liver supernatant fractions the yields of all products formed--except 7 alpha-hydroxycholesterol and 6 beta-hydroxy-4-cholesten-3-one--were markedly decreased.

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A competitive-binding assay confirmed binding to the androgen receptor, with a median inhibitory concentration for radioligand binding of approximately 370 nM. The steady-state behaviour of single sodium channels was recorded in symmetrical 500 mmol NaCl before and after the addition of pentobarbital 0.34-1.34 mmol. There are several case reports in which left ventricular pacing could be possible after successful elimination of coronary vein stenosis by stent implantation or cutting balloon angioplasty. Adolescents with the predominantly hyperactive-impulsive type (ADHD-HI) did not differ significantly from the control subjects in any measure assessed, but had a better performance than did those with ADHD-C on both the Digit Span and the WCST. Oestrogen has the ability to induce CD40-mediated activation of B cells.

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From 1992 to 1999, 31 patients with medial wall pyriform sinus cancer including stage I 1, II 4, III 14 and IV 12 lesions were treated. Unstable angina signals a sudden transition from stable to unstable atherosclerotic coronary artery disease. Micrococcal nuclease digestion was used to probe the structures in which herpes simplex virus type I (HSV-I) DNA is found during virus replication. Intra-class correlation coefficient (ICC) and k statistic were used to evaluate the stability for quantitative variable and categorical variables respectively.

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The bias of the HDIAL and the LDS measurements are -0.54 ppm and -0.99 ppm, respectively. Variables of interest were compared using Student t, Wilcoxon rank sum, chi(2), or Fischer exact tests, as appropriate. We evaluated the radiographic and functional results of locked intramedullary nailing in the treatment of subtrochanteric fractures of the femur.

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Two series of studies are reported dealing with (1) psychophysical characteristics and (2) interactions of visceroceptive and somatosensoric information processing. This suggests that the by-products of fungal culture in the crude CIP solution, presumably polycarbohydrates and proteins, have protective effects on the enzyme against inactivation during catalytic transformation of phenol, and the addition of PEG provides small effects on further protection. We studied how two different hand posture cues affect joint attention in normal observers.

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This shows a relatively constant level up to 2 Hz and then a clear minimum at 60 Hz, in agreement with measured thresholds of squid axons. All received their primary medical care in an 11-county region of southwestern Wisconsin (Health Service Area 1).

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BPPV is characterized by specific otoneurological signs, and must be treated with liberatory maneuvers: neither medical therapy nor strict follow-up is needed. Phytosterols are bioactive compounds in plants with similar cholesterol-lowering properties as vegetarian diets. Neurological manifestations of the Mendelian-inherited autoinflammatory syndromes.

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The effects of vagotomy were studied during periods of oscillator-induced apnea in 11 pentobarbital-anesthetized dogs. To further define egress requirements, we addressed why treatment with the food colorant 2-acetyl-4-tetrahydroxybutylimidazole (THI) induces lymphopenia. Recent Advances in Effect-directed Enzyme Assays based on Thin-layer Chromatography.

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The alternative sigma factor, sigmaS, affects polyhydroxyalkanoate metabolism in Pseudomonas putida. Female hamsters 2 days of age failed to respond to any dose (0.025--1000 ng) of GnRH, while 10-day old females responded in typical dose-dependent fashion. This review discusses the management of ovarian function and participation in the process of a new class of cellular regulators--Gasotransmitters (NO, CO and H2S). Many investigators have suggested that the newborn infant can utilize galactose better than adults and that neonatal galactose assimilation exceeds that of glucose. Adults with dyslexia demonstrate space-based and object-based covert attention deficits: shifting attention to the periphery and shifting attention between objects in the left visual field.

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Care planning for nursing home residents: incorporating the Minimum Data Set requirements into practice. The cell adhesion molecule CD44 is expressed in the central nervous system, especially on glial cells in the white matter, the extracellular matrix of which also contains one of its ligands, hyaluronate.

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Congenital anomalies induced by triamcinolone acetonide in murine embryos. A random, non-stratified study of 100 patients showed that a significantly higher percentage of patients receiving piracetam attain or maintain a normal or near-normal level of consciousness postoperatively than those receiving a placebo. The instillation of anti-p75(NTR) or anti-trkA completely reversed the DEP-induced increases in ventilatory responses and lung IL-4 protein to levels similar to control mice.

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We present an unusual case of a huge broad ligament mass measuring 29x19x09cm, mimicking an ovarian tumour both clinically and radiologically. Multi-Institutional Review of Outcomes and Complications of Robot-Assisted Laparoscopic Extravesical Ureteral Reimplantation for Treatment of Primary Vesicoureteral Reflux in Children.

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Both RFTR and EC techniques could be used as an effective treatment of choice for inferior turbinate hypertrophy, and EC technique is superior to RFTR technique to achieve high efficiency. The current clinical practice for reduction of IOP, after delivery of local anesthesia, is manually administered digital compression. Both interventions were found to increase fruit and vegetable consumption significantly, although only the volitional intervention demonstrated a significant increase in fruit and vegetable consumption over the control intervention. Heterozygotes for the p.Cys282Tyr (C282Y) mutation of the HFE gene do not usually express a hemochromatosis phenotype.