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Using a membrane pull-down assay, we found that Twist directly interacts with p53 and that this interaction underlies the inhibitory effects on p53 target gene expression. Despite attempts to control for the clinical presentation and injury severity of abused children, significant differences in mortality persist between AA and white children.

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The Project also studies the design and effectiveness of behavioral strategies used to minimize error and maximize team performance in safety-critical work settings. This experiment tested the osteoinductivity of demineralized bone powder (DBP) in nonhuman primates. We applied this method to two internal medicine departments and one urological surgery department and we compared the solutions proposed by this method with those put forward by the ratio method. The key intermediate 3-methylenelactams 3 and 3a were obtained from 3-(hydroxymethyl)lactams 2 and 2a by a direct dehydration with dicyclohexylcarbodiimide using cuprous iodide as a catalyst. Effect of phosphate electrolyte buffer on the dynamics of water in tendon and cartilage.

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The use of this information to direct metabolic engineering strategies is illustrated. One emerging approach is the application of Gene Ontology (GO) mapping and pathway analysis to gene expression profiling data. Immunologic markers of attenuation in guinea pigs infected with strains or variants of Junin virus Conclusions are based on the principle that the child inherits half of the characteristics (markers) in his/her blood from each true parent. The role of adjuvant radiotherapy for central neurocytomas (CNs) is not clear.

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Results of this study show that NO pretreatment can protect osteoblasts from oxidative stress-induced apoptotic insults. This article aims to address clinical questions that general practitioners (GPs) may have in identifying and responding to patients experiencing family violence.

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Alternatives to cross-lip and distant flaps in the reconstruction of ablative lip defects. This study identified a moderate level of awareness of a significant existing patient support and research service (the LAM Foundation). Inductive influence of macrophages on cytotoxic properties of lymphocytes.

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Major transplantation antigens in T cell-mediated immunity: a comparison of the transplantation reaction with antiviral immunity. Atrial fibrillatory cycle length, measured in the atria appendages using automated monitoring software, was studied to determine its clinical correlation, the complexity of the ablation procedure, and the AF termination success rate. Demographic data were collected and all postoperative notes were reviewed. The urinary 1-OHP concentrations of the study group were higher than those of the control group when they had the same genotypes for non-smokers. Permeability rose to a sharp peak (10 times control levels) 9 h after oil instillation, but dropped to 5 times control values by 12 h and continued a steady decline over the next 7 days.

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Our data provide the first experimental evidence for the existence of distinct functional regions in Bassoon and suggest that a centrally located CAZ targeting function may be complemented by an N-terminal capacity for targeting to membrane-bounded synaptic organelles. Two major DNA repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), repair double-stranded DNA breaks (DSBs) in all eukaryotes.

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Requests for a copy of BID and for depositing data into CEBS or BID are available at http://www.niehs.nih.gov/cebs-df/. Cleavage of carcinoembryonic antigen induces metastatic potential in colorectal carcinoma. The analysis favors prior vaccination of health care workers unless the likelihood of any attack is very low, but it favors vaccination of the public only if the likelihood of a national attack or of multiple attacks is high. Induction of IgE antibody response in mice after daily treatment with contaminated but not with pure penicillin.

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The system was effective against Escherichia coli and Mycobacterium tuberculosis. The peak pleural fluid level (Cmax(PF) of 2.88 microg/ml) occurred 1 h (Tmax(PF) of 1 h) after infusion and decreased thereafter.

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The method is based on the tip-surface force reconstruction technique and does not require any prior knowledge of the eigenmode shape or the particular form of the tip-surface interaction. It is successful in improving CIM and syringomyelia in patients with no overcrowding (mainly in children) or with reversible overcrowding of the PCF (mainly in adults). Diagnostic stability four years after a first episode of psychosis. Personal experience with butazolidine therapy of rheumatism and other diseases

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These methods are based on the principle that Hg compounds react strongly with sulfhydryl groups in tissues and cells to form Hg-sulfides and also on the affinity of Hg and silver to form an amalgam when placed in a physical developer or photographic emulsion. We used a high speed camera to capture the complete motion of the eye directly and obtain more data during the pressure measurement.

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Polycatenar 2,4,6-triarylamino-1,3,5-triazines, which organize into columnar mesophases and are susceptible to H-bonding interactions, were chosen as a starting point to build up the chiral supramolecular structure. Effects of hybridoma antibodies on invasion of cultured cells by sporozoites of Eimeria.

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After MTX treatment, filgrastim administration was unable to stimulate marrow granulopoiesis as observed in normal mice. Rates of change of magnetic flux were recorded during the study using a custom-built three-axis coil unit connected to a data logger. Oro-dental health in children with chronic renal failure and after renal transplantation: a clinical review.

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Additional advantages of arthroscopy include decreased postoperative pain, early active range of motion, shorter course of rehabilitation, and earlier functional return. To evaluate maternal and paternal smoking habits during pregnancy and determine their correlation with pregnancy complications and newborn status.

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Structure of the Ss blood group antigens, II: a methionine/threonine polymorphism within the N-terminal sequence of the Ss glycoprotein. In the joint, both glenoid and humeral head cartilage experience maximum tensile and compressive stresses are at the cartilage-bone interface, away from the center of the contact area. Intravenous administration of an AVP pressor antagonist had no significant influence on mean arterial blood pressure, cardiac output and total peripheral resistance in SHRSP. We compared percent cover, stem density, and biomass in the treatment marshes to define ecological recovery of the marsh vegetation and soil hydrocarbon content to determine the efficacy of in situ burning as a cleanup technique. The role of H2 receptor antagonist premedication in pregnant day care patients.

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Primary immunodeficiency diseases (PIDs) are a genetically heterogeneous group of disorders that affect distinct components of the innate and adaptive immune system, such as neutrophils, macrophages, dendritic cells, complement proteins, natural killer cells, and T and B lymphocytes. Developmental conditions and subjective experiences of children with a schizophrenic parent--qualitative and quantitative studies from the Mannheim Study of Children at Risk The modularity of the coordination-driven approach to self-assembly has allowed us to systematically study a wide variety of different factors that can control the extent of supramolecular self-organization. Earthquake injuries and the use of ketamine for surgical procedures: the Kashmir experience.

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Synthesis of sugars embodying conjugated carbonyl systems and related triazole derivatives from carboxymethyl glycoside lactones. An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris. Isolated schistosome eggs did not contain collagenase or elastase activities.

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Our results are consistent with the sensorimotor theory, according to which lexicosemantic representations are distributed across brain regions participating in sensorimotor processing associated with the experiential components of lexicosemantic acquisition. By contrast, a complex between antithrombin III and dansyl-thrombin showed no change in polarization up to 70 degrees C, suggesting that the individual components are more stable in the complex. The clinical and pathological findings of 3 patients with acromegalic heart disease are reported. We induced (1) acute systemic inflammation by intraperitoneal injection of bacterial endotoxin (LPS), (2) chronic local inflammation by a turpentine injection in the hind limb and (3) severe pneumonia and sepsis by intranasal inoculation with Streptococcus pneumoniae We found that all aspects of peripheral TH metabolism are differentially regulated during illness, depending on the organ studied and severity of illness. Our data point to a potential benefit of combination therapy with 1,25-(OH)(2)D(3) and MEL in the treatment of breast cancer and suggest that the growth inhibition could be related, at least in part, to the enhanced TGF-beta(1) secretion.

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The computations of the membrane potential and currents, as well as that of the intra and extracellular potential fields, are performed at the same time, within a single finite element software. In our study, SE intensity was not influenced by the use of cannabis. These data demonstrate that necdin mediates intracellular processes essential for neurite outgrowth and that loss of necdin impinges on axonal outgrowth.

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The goal of this study was to assess how pregnancy influences the scoring of the Disease Activity Score in 28 joints (DAS28) and the Health Assessment Questionnaire (HAQ), and how both scores perform in pregnant patients with RA. To date, although genetic studies reported several susceptibility genes with PD, few of them were replicated and the pathogenesis of PD remains to be clarified. We selected randomized controlled trials comparing regional citrate with heparin in adult patients with acute kidney injury (AKI) who were prescribed CRRT. Effects of polypeptides from HCV core region on the function of cytotoxic T cells

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The prevalence of opportunistic infections and the mortality have decreased considerably since early in the epidemic. Both patients, with advanced disease resistant to conventional therapy and treated for six or more months with rhu-IFN-alpha 2-arg, achieved complete clinical remissions. Although interpopulation variation in susceptibility was observed, the magnitude of the differences was comparable with the variability observed between generations of the same population. Increased investigative effort is warranted for these approaches which offer significant potential as an adjunct to conventional forms of dialysis.

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The molecular weight of the untreated HC protein was about 48,000. Changes in cytokeratins following treatment of hamster cheek pouch epithelia with hyperplastic or neoplastic agents. Moreover, emerging data suggest that individual Hsp70 proteins can bring about non-overlapping and chaperone-independent functions essential for growth and survival of cancer cells. Analysis of the physiopathology of the syndrome points to sodium and water deficits as the principal cause of symptoms.

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Reactivity of a monoclonal antibody with tissues and tumors from the human breast. The specific protection was reflected by the lower morbidity by influenza-like respiratory infections and by the absence or scarcity of postinfluenza complications in vaccinees.

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This inhibitory effect down-regulates HGF-stimulated single cell migration, and limits branching morphogenesis at both the single cell and multicellular level. Breaking aggregation in a tetrathiafulvalene-fused zinc porphyrin by metal-ligand coordination to form a donor-acceptor hybrid for ultrafast charge separation and charge stabilization.

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The purpose of this study was to determine the failure rate of monolithic zirconia restorations due to fracture up to 5 years of clinical performance. Although WMH was not strongly associated with disease severity or cognition, it may provide a characteristic neuroimaging parameter in the study of AD development. About one fourth of accessions were heterogeneous for botanical descriptors and a seed protein profile.

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It is evident that the hospital did not use patient complaints as a source of learning that could have promoted higher standards of care. This on-line PGC-ESI-MS/MS method shows good linearity over the concentration range 0-100microM, selectivity, short analysis time, and limits of detection of 0.1microM for disaccharides trehalose (Tre), sucrose (Suc), and maltose, and 1.5microM for hexose phosphates fructose-6-phosphate (Fru6P), glucose-1-phosphate (Glc1P), and glucose-6-phosphate (Glc6P), and phosphoenolpyruvate (PEP). To describe the clinical manifestations, laboratory findings, and molecular genetic studies in a Taiwanese family with type I HAE with paternal mosaicism. Cataract extraction surgery appears to affect pupil size and shape, possibly in correlation to AC depth increase.

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Lesions of the oral mucosa: an epidemiological study of 23785 Mexican patients. Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast. The preparations of transferred intact colonies had cells with distinct cytoplasm and clear cellular outlines and a background without disturbing masses of stained agar.

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The effect of increasing bulk Ni is to encourage the formation of clusters with significantly higher Ni content, slightly higher Mn and Si contents and significantly lower Cu contents. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future. Placental protein 12 (PP12) was measured by radio-immuno-assay in serum and endometrial extracts of 25 women at various phases of the menstrual cycle, and in the decidua from six women undergoing legal abortion in early pregnancy. Using the adverse surgical effects criteria modified from the G.O.G., the clinical course of this group of patients was analyzed, retrospectively.

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We propose a one-fluid analytical model for a turbulently flowing dilute suspension, based on a modified Navier-Stokes equation with a k-dependent effective density of suspension rho(eff)(k) and an additional damping term proportional, variant gamma(p)(k), representing the fluid-particle friction (described by Stokes law). The authors suggest ways in which these hypotheses could be tested by presenting explicit predictions and suggesting suitable test species or conditions. A retrospective case series has inherent limitations when results are compared with randomized controlled trials.

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To determine the prevalence of the metabolic syndrome (MetS) and its components in Brazilian women with polycystic ovary syndrome (PCOS). The effects of both symmetric and asymmetric peripheral hearing loss on the masking level difference (MLD) at 500 Hz were studied in 651 subjects with conductive or sensorineural hearing loss and 270 normal controls. Resolving capacity of monosomic line analysis as a method of cytogenetic investigations of wheat was demonstrated. Relationship between the polymorphisms of GDI1, children NSMR and their intelligence in Qinba region

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We point out the relation of the considered systems with cyclic polychronous groups and show how the assumed delay configurations may arise in a self-organized manner when a spike-time dependent plasticity of the connection delays is assumed. The characteristic points were found to be appeared obviously on pH profile at both ends of ammonia oxidization and denitrification by analyzing the mechanism of biological nitrogen removal and the balance of carbonic acid. The literature on this subject and cases reported so far are reviewed, including the association of other atypical antipsychotic drugs also involved in endocrine disorders. However, it is not yet known whether Etv4 family members are expressed in the ovary or play any role in ovarian functions.

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The purpose of this study was to identify whether the couple perceived breast cancer as a traumatic event, to evaluate the association among posttraumatic growth, dyadic adjustment, and quality of life and to explore the predictors affecting quality of life of the couple. This is the largest linear accelerator radiosurgical series, and the second largest radiosurgical series reported to date.

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Determination of four kinds of environmental endocrine disruptors in blood serum of precocious puberty patients by high performance liquid chromatography In comparing patients not in labor, the immunostaining for progesterone receptors was less at term compared with preterm pregnancy. In three cases, defects were located on the upper one third of lower leg and in the other cases, on the knee. The development of quantitative PCR assays has been crucial in meeting these needs.

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The effects on eNOS expression mediated through rosuvastatin could be reversed by treatment with mevalonate indicating inhibition of HMG-CoA reductase as the underlying mechanism. We used palmitate to simulate a high free fatty acid condition for C2C12 myotubes in vitro and administered t10, c12-CLA across the groups. The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells. On the other hand, the evaluation of risk factors and determinants is a necessary prerequisite for any effective intervention.

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Calculations show that the silicon isotope correlations in those large SiC particles can be generated only in the most massive carbon stars. The discovery and characterization of Mimivirus, the largest known virus and putative pneumonia agent.

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This had lead to the general view of a good quality of life of these children. No peak could be observed in the voltammograms after CPE, indicating the absence of any electroactive substance left in the solutions.

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While physician informational needs have been examined in the literature, rarely do the findings have the specificity required to drive development of Electronic Medical Records (EMRs) features. A total of 1,081 lncRNAs, including 965 intergenic lncRNAs (lincRNAs), 59 intronic lncRNAs, and 57 antisense lncRNAs (lncNATs), were identified using our newly developed pipeline.