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Quality of life and Marilyn Monroe: which language do they speak? Compared to catheter-based interventions there is evidence that conventional CABG offers significant advantages over PCI. Identification of the plasmid-encoded immunity protein for colicin E1 in the inner membrane of Escherichia coli. We combine our experimental results with data from previous studies of molecular polymorphism in this species. This is also true for families in which only tuberculoid leprosy is found, which is by far the commonest type in the population studied.

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Abnormal cilia were demonstrated in the lining epithelial cells of three cases of intraspinal endodermal (bronchogenic) cyst. The drift time of this small protein and its peptic peptides did not noticeably change due to solution-based deuterium incorporation. Responseiveness was found to be controlled by an Ir gene located in the K end (K and/or I-A subregions) of the H-2 complex.

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Hypotelorism, nasomaxillary-hypoplasia and cleft lip and palate in a patient with normocephaly and normal intelligence--a case report. Electromyographic abnormalities in the left medial gastrocnemius muscle were still present at three- and six-month follow-up. We undertook an unbiased metabolite profiling of fibroblasts from schizophrenia patients and healthy controls to identify metabolites and pathways that are dysregulated in disease, seeking to gain new insights into the disease biology of schizophrenia and to discover potential disease-related biomarkers.

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Since monocrotaline (MCT)-induced pulmonary hypertension in rats is characterized by proliferation of pulmonary vascular smooth muscle cells, we hypothesized that PPARgamma ligands may reduce MCT-induced pulmonary hypertension. On the basis of histopathological analysis of a small set of MS cases, a recently published study postulates primary oligodendroglial damage as the initiator of MS lesions, with infiltration of leukocytes into the central nervous system (CNS) as a secondary phenomenon.

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Repeated cocaine administration (20 mg/kg ip every hour for 3 h, for 5 days) had no effect on the proenkephalin and prodynorphin mRNA in the central nucleus of the amygdala. In 24 children with GMN, we analyzed: localization, main nevus diameter, satellite nevi, brain MRI, catecholamines concentrations in 24-h urine collection, surgery stages number, and histological examinations. We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia. Idiotypic-like interactions between mAbs directed against cytidine (Cyd) or guanosine (Guo) nucleosides were characterized. Enamel thickness after preparation of tooth for porcelain laminate.

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For cerium and titanium, background levels from natural sources make measurement of ENMs difficult to quantify. In order to study the effect of LMWH on the behavior of MLV-LMWH in blood, osmotic fragility (in saline and plasma), hemolytic activity, and plasma recalcification time tests were carried out.

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Service use and unmet needs in youth suicide: a study of trajectories. MIA on GD9 or GD17 led to increased basal locomotor activity, enhanced motor responses to ketamine, a psychotomimetic drug, and reduced time spent in the center of the arena, suggesting an increased anxiety-like behavior. In this paper, we study two theoretical models of inter-filament cohesion in the opposite limit, in which filaments are sufficiently flexible to maintain cohesive contact along their contours, and address, in particular, the role played by helical-interfilament geometry in defining interactions. Despite advances in our understanding of the complex genetics and biology of AML pathophysiology, these findings have been translated to the clinic with only limited success, and poor outcomes persist for the majority of patients. Ion channels are also targets for drug discovery and new receptor-based analytical technologies.

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In 3 of 4 infants with Clostridium perfringens, the necrotising enterocolitis was fulminant, characterised by severe pneumatosis intestinalis, extensive gangrene, early intestinal perforation, and a fatal outcome. The objective of the study was to evaluate the incorporation of preoperatively administrated PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) into cell phospholipids. The distribution of(14)C-labeled cholesterol in the dog: Effect of long-term epinephrine administration.

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Optimizing care for GI disorders in children after hematopoietic stem cell transplantation. Diabetes mellitus is not a contraindication to TOL after Caesarean section (II-2B). The clinical success of modern dental ceramics depends on an array of factors, ranging from initial physical properties of the material itself, to the fabrication and clinical procedures that inevitably damage these brittle materials, and the oral environment. Our assessment of the impacts of the 1998 mass bleaching event on coral cover, reef structural complexity, and reef associated fishes spans 7 countries, 66 sites and 26 degrees of latitude in the Indian Ocean. Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed.

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A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death. DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Adolescents with more sexual knowledge had less positive sexual attitudes and did not show increased practices of safe sex behaviour. Enzyme levels were measured after in-vitro incubation of monocytes with or without stimulation by zymosan and endotoxin. Microgram amounts of polyanion suffice to produce the color changes and the spectral shifts vary with the type of polyanion.

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Tremendously expanded lymphoid progenitor cell compartments in the RF/J mice may reflect the presence of numerically increased sensitive targets subject to radiation-induced damage and transformation. Impact of hemodialysis on the level of high-sensitivity cardiac troponins T in patients with end-stage renal disease. We demonstrate that size-selective directed assembly of nanoparticle films from solutions containing a bimodal distribution of particles can be realized by exploiting the cooperativity of DNA binding in this system. The ideal treatment for acute acromioclavicular joint dislocation is still controversial, both in terms of indications and surgical technique.

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Text detective: a rule-based system for gene annotation in biomedical texts. Paclitaxel, ifosfamide and nedaplatin chemotherapy appears to be effective when used as first or second salvage treatment in advanced relapsed germ cell tumors. Participants completed a retrospective pre-post assessment of their perceived confidence in performing interview, clinical, teaching, and self-awareness skills. Viruses target the central nervous system (CNS) incidentally, due to complications of systemic infection, or specifically, by ascending via the axons of peripheral and cranial nerves. Here, we present the pipelines used in one such project, devoted to the design of novel potent and selective antagonists for the different adenosine receptors.

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Randomized clinical trials have demonstrated that the use of statins in heart transplant patients lowers cholesterol levels and significantly reduces mortality and the development of transplant vasculopathy. These five genes have been isolated by molecular cloning and the nucleotide sequences of four of them have been determined.

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The implantation was the first-line intervention in 48 patients (the bridge group), and was performed after a period of ECLS support in 49 others (the BTB group). It is well established that ghrelin is produced by endocrine cells in the gastric mucosa. Even over the short term, it is difficult to ascertain whether new prosthetic designs have improved patient function as well as has been implied by the related biomechanical studies.

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The concentration of antibacterial IgA expressed as a function of total IgA was as much as 1550 times greater in the EPS than in the serum. Preliminary study on maturity of retinal vascularization in premature infants The comparative effects of pneumoperitoneum on apoptosis and p53 expression in gastrointestinal organs. OCT scans were performed on 28 healthy eyes with the RTVue-100 FD-OCT (Optovue Inc., USA), the Cirrus HD-OCT (Carl Zeiss Meditec Inc., USA) and the Stratus OCT 3000 (Carl Zeiss Meditec Inc.). Recently, both clinical and bench research has begun to provide scientific validation for the use of certain botanical ingredients.

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Several problems which are found in biomonitoring studies are discussed. The importance of the medial temporal region in the recall of spatial location has been confirmed also and novel virtual reality paradigms are now providing insights into the cerebral representation of spatially-extended large-scale environments. In line with this, T cells expressing increased GTP-RhoA failed to form an intact cytoskeleton and to migrate toward a chemokine gradient. Nicotine-induced chemoreceptor response was evaluated using bolus doses of nicotine given before and after propofol 10-500 microM.

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Until such time as higher quality evidence is available about other nursing interventions, the reviewers suggest that the prime nursing action should be the identification of whether older persons receiving community nursing care might have a mental health disorder and, if so, then collaborative referral is made to appropriate services. A new qualitative model for the photoactivation of QD in various environments is developed. One method to acquire dual-energy (DE) computed tomography (CT) data is to perform CT scans at 2 different x-ray tube voltages, typically 80 and 140 kV, either as 2 separate scans, by means of rapid kV switching, or with the use of 2 x-ray sources as in dual-source CT (DSCT) systems.

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Interviews with purchasers were conducted in several geographic areas. The importance of protein kinase C (PKC) and p38 in the regulation of CXCL8 and IL-6 was also examined. Forty-eight hours after the treatment, cytotoxic reaction and apoptosis induction were observed in the gemcitabine only and bortezomib only groups. They may drive tumor progression, although the mechanisms involved are still poorly understood. A concave contact surface with a radius of curvature of 10.5 mm creates a distribution of forces between the central contour matching area of the tip and the cornea that equals the forces generated by the internal pressure of the eye.

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An enhanced level of mutagenesis was observed when steroid-treated E. A novel assay for measurement of HCV NS3 serine protease activity was developed for screening of HCV NS3 serine protease potential inhibitors. A 16-month study with initial double-blind randomization to 50 U of BTX-A or placebo per axilla.

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We conducted a cross-sectional survey to assess the impact of an ITN social marketing programme on Plasmodium falciparum infection and anaemia among children in urban Malawi. The discrepancy between the vast numbers of proteins we encounter and the limited number of proteins that actually become allergens have led scientists on a quest to discover what unique features exist that make proteins destined to be allergens. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Neurofibrosarcoma - complicating neurofibromatosis-I: case report and review of relevant literature.

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Methodological quality of meta-analyses on treatments for chronic obstructive pulmonary disease: a cross-sectional study using the AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool. At this level, it is both plausible and now proven that anesthetics can enhance aggregation of some disease-causing proteins. Light-driven translocation of phototransduction regulatory proteins between the inner and outer segments of photoreceptor cells plays a role in the adaptation of these cells to light. Calcium-dependent regulation of the membrane potential and extrajunctional acetylcholine receptors of rat skeletal muscle.

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Compared to traditional planar electrodes, porous GaN electrode can detect lower concentration of Ag(I) as it possesses more deposition sites (crystal defects) and larger surface area. 180 ASA physical status I and II women patients undergoing elective gynecologic surgery. We have investigated both traditional endpoints as well as other parameters such as sex determination, maturation, molting or embryogenesis in order to evaluate the sensitivity and possible use of these endpoints in ecological risk assessment.

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Six antigenic epitopes of VP6 of BTV were identified and mapped by immunoblot analyses and enzyme-linked immunosorbent assay with oligoclonal antibodies. We summarized and discussed recent findings on the roles played by Rabs in neurons and glia in the central nervous system, and speculate on future directions. A tomato (Lycopersicon esculentum Mill.) glycerol-3-phosphate acyltransferase gene (LeGPAT) was isolated. Using the double-receptor-mediated pathway of viral infection, in this study we synthesized a novel non-viral vector based on PEI combined with two peptides recognizing FGF receptors (peptide YC25) and integrins (peptide CP9) on the cell surface.

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This experience is reviewed here and updated using more recent data. The correlation coefficient between IPSS and SHIM scores were determined, and the scatter diagram was made. Recent surveillance studies have demonstrated trend towards more seriously ill patients suffering from multidrug-resistant nosocomial infections. Effect of suspended-sediment concentration on nitrification in river water: importance of suspended sediment-water interface.

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Despite best practice, it may not be achievable in some patients to reach the optimal goals of secondary prevention recommendations for various reasons, such as co-morbidity, contraindications for some drugs or side effects. Laparoscopic CBD exploration for choledocholithiasis can be performed safely in children at the time of cholecystectomy and can clear all of the stones in the CBD in two thirds of cases. Solids with strongly correlated electrons, in which even subtle crystallographic distortions can result in colossal changes of the electronic and magnetic properties, could be directed between competing phases by such selective vibrational excitation. Optimal management should not only focus on symptom relief through medication and physiotherapy, but should also take into account the psychosocial burden of the disease on the patients and their caregivers. Considerable reanalysis of the state inventories is required before they can be added to yield a larger-scale inventory.

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crystallinum is partially under developmental control and that CAM is inevitably expressed in mature plants. Effect of postoperative analgesia with flurbiprofen axetil and sufentanyl on metabolism of surgical patients with intestinal carcinoma Reproductive success, early life stage development, and survival of westslope cutthroat trout (Oncorhynchus clarki lewisi) exposed to elevated selenium in an area of active coal mining. Gene expression patterns and, even more so, loss of genetic information, especially for myoglobin (Mb) and haemoglobin (Hb) in notothenioid fishes, reflect the specialization of Antarctic organisms to a narrow range of low temperatures.

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Homozygosity for the short GGC allele may be linked to the increased risk of early-onset breast cancer after OC exposure in high-risk women. In addition to the alpha-helical form that is peripherally-attached to vesicles, a substantial portion of alpha-synuclein is freely diffusible in the cytoplasm. Glandular buds were first observed at the 12th fetal week and glandular distribution became evident from the 16th fetal week. The diversity and specialization found in biological molecules, pathways, and cells is staggering, and should be exploited for therapeutic use. Synthetic platelets typically comprise nanoparticles surface-decorated with peptides or ligands to recreate specific biological characteristics of platelets, including targeting of wound and disease sites and facilitating platelet aggregation.

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These results suggest that contrast kinetic studies may be useful in differentiating radiation damage to normal brain tissue from a malignant brain tumor. Patients with chronic hepatitis C virus (HCV) infection who consume large quantities of alcohol have more severe liver disease compared with HCV patients without a history of alcohol consumption. The intramolecular dimeric form of the dye can be described as a clam-shell complex with two interacting hydrophobic carbocyanine moieties.

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The numbers of component blood products transfused in the first 24 hours using TEG/PM were calculated. There exist inherent problems with previously described classification schemes for head and neck lymphatic malformations in children and lack of guidance for management.

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Assessment of cardiovascular risk during peritransplant period in renal transplant recipients. In the present study, we have identified species-specific housekeeping genes (HKGs) for Chinese Hamster Ovary (CHO) cells using data from microarray gene expression profiling. We therefore carried out the present study in which house sparrows (Passer domesticus) were subjected to both 6-h advance and 6-h delay phase-shifts of the light-dark cycle before and after the pinealectomy, and the rhythms in locomotion and feeding were recorded. A profound neutrophilic pleocytosis was detected on analysis of cerebrospinal fluid. Both defects could be fully complemented by addition of purified gyrB protein.

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At the ultrastructural level labeling was mainly restricted to endo- and plasma membranes showing characteristic unequal distribution in various neuron parts. Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus. Indole-3-ylsulfonyl acetate tris-(2-hydroxyethyl)-ammonium is an effective antioxidant and cell membranes stabilizer.

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It may be clinically useful for transvaginal ultrasound examination. Intensive chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is effective for refractory systemic lupus erythematosus (SLE). It has been possible to locate 32 operative procedures that have been published in the Japanese literature over the past ninety years. Frequency, patient characteristics, and outcomes of mild-to-moderate heart failure complicating ST-segment elevation acute myocardial infarction: lessons from 4 international fibrinolytic therapy trials. Improvement in the management of bacteremic pneumococcal pneumonia has the potential for improving the survival for severe pneumococcal pneumonia.

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Systemic therapy for disseminated basal cell carcinoma: an uncommon manifestation of a common cancer. Hence, we propose in this work the first learning-based model that improves the segmentation of an input 3T MR image with any conventional segmentation method, through the reconstruction of a higher-quality 7T-like MR image, without actually acquiring an ultra-high-field 7T MRI.

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While formation and integration of these neural networks is dependent on the action of multiple proteins, converging lines of evidence indicate that genetically controlled variability in the expression of the 5HT transporter (5HTT) is critical to the development and plasticity of distinct neurocircuits. Possibly, prevailing C II formation tends to cause large insulin requirements, although C II may seldomly be detected in the blood, because of rappid trapping. Two genes, Nur77 and NOR1, members of NR4A orphan nuclear receptor family, were expressed at a significantly higher level in AD patients than in healthy volunteers. Improvement of the delivery of exogenous enzymes is essential to achieve effective enzyme replacement therapy in lysosomal storage diseases. We now define distinct signalling mechanisms that regulate lipopolysaccharide (LPS)-mediated induction of IL-12 p40 and p35 in macrophages and which may therefore provide therapeutic targets for precise and specific fine-tuning of cytokine responses.

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Despite the increased I-131 uptake in the tumor, I-131 treatment only transiently controlled the hyperthyroidism and had no effect on tumor size. The recurrences usually took the form of transitory ischemic attacks. Decreased expression of JA-responsive genes, such as VSP1, VSP2, AtJRG21 and LOX2, following wounding in the mutants compared to the wild type reflects the reduced JA levels of the mutants. Selective survival of beta 1-adenergic receptors in rat cerebellum following neonatal x-irradiation.

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Abdominal pain, reflux symptoms, indigestion and the ability to eat and sleep improved in both PUD and G/D patients 1 year after H. Here, we show that histone deacetylase inhibitors (HDI) upregulated ERbeta protein levels, whereas it decreased ERalpha expression.