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The herpes simplex virus type 2 protein ICP10PK: a master of versatility. Acceleration of murine AA amyloid deposition by bovine amyloid fibrils and tissue homogenates. Dynamic cardiomyoplasty is a surgical procedure which could support myocardial function when cardiac insufficiency would become pharmacologically intractable in the mid term. Here we report that a six-residue peptide (five of them native) of MBP can induce EAE.

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Dipropylacetate (DPA) is an anticonvulsant, which has been successfully used in the treatment of several types of epilepsy. These studies characterize the in vivo clearance rates of AAV vectors for the first time and guide the development of future strategies for the avoidance of antibody-mediated AAV vector neutralization.

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Medroxyprogesterone, dexamethasone, or cortisone, locally applied in sustained release polymer to rabbit V2 carcinoma implanted in the rabbit cornea, blocked neovascularization and three-dimensional growth of the tumor. Psychotic disorders among homeless subjects attending a psychiatric emergency service.

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Results of skin tests obtained with a fraction of sperma plasma separated by chromatography are indicating that the antigen is of protein nature with a molecular weight of about 14.100. Our work suggests the possibility that p53 facilitates high-fidelity DSB repair while playing little or no role in mutagenic NHEJ. It remains unclear whether the replication of live attenuated vaccine viruses will be similarly enhanced when administered to Dengue-immune individuals.

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Polyphenol oxidase (PPO) may have multiple functions in tissues depending on its cellular or tissue localization. accumbens and TXB2 in the hippocampus, and reduced 6-keto-PGF1 alpha and TXB2 in the cortex.

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From the simulated fibers we compute a connectivity map that gives an indication of the probability that two points in the dataset are connected by a neuronal fiber path. This study further demonstrated the complexity of factors playing a role in mediating the physiological response to social stress resulting in considerable individual differences in the response to stress. These results have implications for our understanding of normal prostatic growth and development and of the pathobiology of human prostate cancer. In fos-1 mutants, the gonadal anchor cell extends cellular processes normally toward vulval cells, but these processes fail to remove the basement membranes separating the gonad from the vulval epithelium. Our data indicate a need for further studies to address the full range of environmental factors other than smoking that may be associated with citrullination and RA.

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The pathophysiology of botulinus intoxication is discussed with a consideration of the literature and the results of this study. Incidence and prognostic significance of positive peritoneal lavage in colorectal cancer. 3H thymidine uptake was decreased at 5 days from controls with AMD and ADR, and increased at 14 days from controls with ADM, VCR, and ADR. A substantial number of infants attending routine universal primary care are at risk of developing mental health problems.

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The influence of the putative outer membrane autotransporter (OmaA) protein to the persistence of Brucella suis was investigated. To evaluate the effectiveness of a multifactorial fall prevention program in prespecified subgroups of nursing home residents.

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Pre-incubation of THP-1 monocytes with human recombinant fractalkine as well as silencing of CX3CR1 expression in THP-1 monocytes significantly impaired their adherence to BeWo cells and primary term trophoblasts. Detection of severe acute respiratory syndrome coronavirus in stool specimens by commercially available real-time reverse transcriptase PCR assays. The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) is a research project aimed at identifying risk and protective factors for suicide and related mental health outcomes among Army Soldiers. Here we report a patient who had meningitis as a cause for his pneumocephalus.

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Our results show that mutation of a single GXXG motif generally had no effect on binding, but the mutation in any two KH domains, with the exception of the combination of KH3 and KH4 domains, completely abrogated RNA binding in vitro and significantly retarded granule formation in zebrafish embryos, suggesting that any combination of at least two KH domains cooperate in tandem to bind RNA efficiently. Rates of diagnosis of six diseases of Holstein cows during 15-day and 21-day intervals. Viruses have been shown to encode trans-regulatory small RNAs, or microRNAs (miRNAs), which bind to messenger RNA and negatively regulate host or viral gene expression.

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No staining was obtained either in the contralateral hemisphere or outside of ischemic areas. Scanning and transmission electron microscopy were used to study the early ocular response to infection by Pseudomonas aeruginosa inoculated under the fused eyelids of immature mice. Bioengineering bridging materials should ideally act as cell carriers for the implantation of axon growth-promoting glia, as well as supporting integration with host cell types. Aldehyde-functionalized benzenediazonium cation for multiprobe immobilization on microelectrode array surfaces. Increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis.

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The aim of the present study was to investigate quantitatively the sampling variability of needle liver biopsy on the assessment of liver fibrosis/cirrhosis. Socioeconomic factors influencing exclusive breastfeeding among primiparous women in Abidjan (Ivory Coast)

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Gastroenterologists are frequently requested to perform endoscopic procedures to rule out cancer or other serious GI disease before major surgical operations. Although there is a considerable body of evidence suggesting increased activity of the fetal and neonatal adrenal in the rabbit, the mechanism responsible for this increased activity has not yet been determined. Here we report a study of two natural MC1R loss-of-function variants, Leu93Arg and Arg162Pro, and two artificial mutants, Cys35Ala and a deleted form missing the last five amino acids in the carboxyl tail. DNA fingerprinting elicited evolutionary trend of oral Candida tropicalis isolates from diverse geographic locales. In this paper, we review the studies that investigated both structural brain asymmetry and asymmetry of functional connectivity in healthy subjects and SCZ.

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The traditional diagnostic standard of open biopsy yields highly accurate diagnoses but associated with it is a significant rate of procedural complications. Automated immunoassays for the autoantibodies to carbamylated or citrullinated telopeptides of type I and II collagens.

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One of the constituents, light-activated pseudohypericin, was necessary, but not sufficient to explain the reduction in LPS-induced PGE2 of the 4 component system. Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression. Inhibition of inflammatory responses by leukocyte Ig-like receptors. dose of morphine sulfate was noted in 6/12 no-minipump controls and 4/9 saline-infused controls.

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Advances in Molecular Diagnosis of HBV Infection and Drug Resistance. Cell-associated sensing elements might also be involved in modulating the bacterial growth even in the presence of non-limiting (although declining) nutrient concentrations, thus promoting their economical utilisation in dense populations. Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands. Turnover of dopamine (DA), serotonin (5-hydroxytryptamine) (5-HT), noradrenaline (NA) and their metabolites has been measured in control and aged rats. However, a prolonged seizure and deterioration of consciousness appeared on the sixth day of illness.

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In demonstrating considerable changes in land bird community structure, our results suggest that ecosystem function in urban areas may be severely compromised. In mitochondria isolated from untreated hearts, both Ru360 (10 microM) and RR (1 microM) decreased pore opening, while spermine (20 microM) increased pore opening which was blocked by CsA (0.2 microM). To investigate the potential of novel postprocessing and visualization techniques to distinguish presence of collateral flow using Bolus Tracking MRI. In the presence of a catalytic amount of Re(CO)(5)Br, the coupling of epoxides with supercritical CO(2) without an organic solvent at 110 degrees C has afforded cyclic carbonates in good to excellent yields.

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The Rockefeller University Center for Clinical and Translational Science supports a centralized recruitment core, call center, Research Volunteer Repository, data infrastructure, and staff who provide expert recruitment services to investigators. This potential relationship should be further evaluated in future studies.

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Whether immune-modulation in acute pancreatitis remains a fact or just fiction remains to be seen in the future. Use of NAATs for STD diagnosis of GC and CT in non-FDA -cleared anatomic specimens.

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Intraclass correlation coefficients were used to assess the test-retest and interrater reliability of each of the FLEE tests. The application of a mask between the electric field electrodes allowed to selectively pattern areas that are exposed. The authors, date, journal, study type, population, main outcome measures and results were tabulated. The dermal ridge patterns and palmar creases of trisomy 9p which are most helpful from a diagnostic standpoint are zygodactylous or absent palmar digital triradii, brachymesophalangy, reduced total finger ridge count, complex thenar/ID I patterns, transverse palmar ridge alignment, simian creases, distal axial triradii, and great toe and hallucal arch patterns. This suggests that non-O ADA2 carrier genotypes may lose in the reproductive stage the selective advantage accumulated during the early stages of development.

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Neurotrophic factors (NTFs) are well known for their actions on neuronal survival in the peripheral nervous system. Relative to subcutaneous tumors, WAT and BAT tumors grew at accelerated rates along with improved neovascularization, blood perfusion, and decreased hypoxia. The heat-labile enterotoxin (LT) has been isolated in homogeneous form with high specific activity from three sources: cell-free supernatant, NaCl extract, and whole-cell lysates of an enterotoxigenic Escherichia coli strain. Fluorescent and radiolabelling of pepsin-digested human glomerular basement membrane with a newly developed hydroxy-coumarin derivative (CASE).

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Most of the compounds were able to inhibit Nile Red efflux indicating that they are substrates of the AcrB efflux pump. These results strongly suggest that EGCG suppresses the PGD2-stimulated induction of HSP27 at the point between Raf-1 and MEK1/2 in osteoblasts. A differential drug screen for compounds that select against antibiotic resistance. Given the increased interest in the economic evaluation of healthcare interventions, this article briefly defines various forms of economic evaluations and describes some useful steps for conducting appraisals of cost-effectiveness analyses.

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Both tests were equally sensitive and specific in detecting HSV antibodies. We also find that size decrease and plate-like morphology are beneficial for the performance improvement of LiMnPO4.

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Poor adherence is thought to be one of the major common causes of uncontrolled high blood pressure over the world leading to useless drug dose or class changes which may lead to increased adverse effects and medical costs. He completed a rigorous Army physical fitness test 7 days postinjury and the Marine Corps Marathon 47 days postinjury. Leucovorin supplementation and withdrawal of the treatment, improved MTX caused effects partially. Spaced repetition decreased (false) recognition of paraphrases as compared to the other two conditions.

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Metabolic utilization also improved with increased pH of the soaking solution, although the values were, in general, low as a result of urinary losses under the experimental conditions. Using orbital tuning, we estimate deposition of the Elmo horizon at about 2 million years after the Palaeocene-Eocene thermal maximum. Occurrence of several arsenic compounds in the liver of birds, cetaceans, pinnipeds, and sea turtles.

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Antiseptics containing iodine are relatively cheap, resistance is unknown and concerns about systemic toxicity are probably overstated. Using blind whole-cell recording techniques on rat hippocampal slices, the function and mechanisms of several leak subtraction methods of Axon patch clamp system (Axopatch amplifier and pClamp software) were analyzed. Kgp-rHArep induced both a Th1- and Th2-type response following i.n. Estimates from difference-in-difference models indicate that the introduction of same-sex marriage or of alternative institutions has no negative effects on family formation.

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Seventeen patients with Type 1 Diabetes Mellitus on CSII (previously on MDI) and 17 patients on MDI, matched for age, gender, BMI and duration of diabetes, were retrospectively studied. Measurements of bottom velocities and sediment collected in traps, as well as damage to moorings and equipment, captured the signatures of frequent energetic events. Malignant pleural mesothelioma (MPM) is an aggressive tumor linked to environmental/occupational exposure to asbestos, characterized by the presence of significant areas of hypoxia.

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Structural transitions in the tetrameric melittin from bee venom in 2 M KCl induced by variations of pH (from 0.7 to 12.0) and temperature (from 2 to 95 degrees C) have been studied. Development and validation of a new technique for estimating a minimum postmortem interval using adult blow fly (Diptera: Calliphoridae) carcass attendance.

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by increasing plasma HDL-cholesterol concentration and decreasing triglyceride level. Pim2 complements with Flt3-Wt signaling to induce proliferation by enhancing G(1)/S-phase progression of the cell cycle. This interim final rule also sets forth and invites further comments on the State requirements for conducting eligibility reviews and estimating payment error rates due to errors in eligibility determinations. Immunological tests on cervical mucus in patients with chronic endocervicitis revealed differences in the total number of leukocytes, content of living cells, functional activity of neutrophils, concentration of immunoglobulins and proinflammatory cytokines. Abnormal development of the spine occurs early in life and also interferes with usual development of the skin.

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In comparison with other Caprinae DRB sequences, the Rupicapra alleles displayed a species-specific clustering that reflects a large temporal divergence of the chamois from other caprinids, as well as a possible difference in the selective environment for these species. Thus, we next investigated a biophysical mechanism by which insulin signaling could be disrupted and found that disruption of lipid microdomains via cholesterol depletion blocks insulin-induced Akt activation and reduces insulin receptor tyrosine phosphorylation.

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The observation that reoperation increases risk for further complications three-fold suggests the less common proximal repairs and reoperations should be subspecialized so that designated surgeons can gain greater expertise. Genomes contain tandem repeat blocks that are at risk of expansion or contraction. We measured the levels of six endothelial growth modulators, four angiogenic growth factors and two inhibitors of angiogenesis in 35 untreated acromegalics, 36 untreated GH-deficient subjects and 101 normal control subjects.

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Excessive calcium is thought to be a critical step in various neurodegenerative processes including ischemia. A novel potent anti-allergic drug in the treatment of hay fever.

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There is still a great deal of debate regarding the best route for cell transplantation. The intracellular control of aromatase activity by 5 alpha-reduced androgens in human breast carcinoma cells in culture.

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Number of tobacco users admitted to treatment increased significantly, while the number of tobacco users who left treatment early did not significantly change. Ototoxic factors requiring consideration in the diagnosis of occupational hearing loss Proceedings from the 5th International Conference on Bioinformatics of Genome Regulation and Structure 2006. aeruginosa QS signaling, suggesting that solenopsin A targets the C(4)-HSL-dependent rhl QS system.