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The National Institute for Health Research Health Technology Assessment programme. Increased calcium-channel currents of pancreatic beta cells in neonatally streptozocin-induced diabetic rats. Vascularization, cellular behavior, and union of vascularized bone grafts: experimental study in the rabbit. The brain is organized into networks composed of spatially separated anatomical regions exhibiting coherent functional activity over time. Metastases were proved in 14 of 39 patients with peripheral versus 135 of 277 patients with central carcinoma.

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Genetic research has moved from Mendelian genetics to sequence maps to the study of natural human genetic variation at the level of the genome. Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and the expression increases with tumor aggressiveness, metastatic disease, and recurrence.

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In spring 2001, we surveyed by mail all physicians practicing obstetrics in Utah. Antiphagocytic effect of Pseudomonas aeruginosa exopolysaccharide.

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Fat redistribution and adipocyte transformation in uninephrectomized rats. Hypoxia can stimulate up-regulation by of MANF expression over time, suggesting that MANF may play a vital role in the functional regulation of RGCs both in health and disease. Genes on the mammalian X chromosome may be under unique evolutionary pressure due to their hemizygous expression in males. The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone.

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Identification of neuron-related genes for cell therapy of neurological disorders by network analysis. Use of KL-3 glue in combination with antibiotics in emergency and selective abdominal surgery

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Thyrotoxicosis and a thyrotropin-secreting pituitary tumor causing unilateral exophthalmos. Cultured megakaryocytes: changes in the cytoskeleton after ADP-induced spreading.

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The higher net MMP-9 (but not MMP-2) activity in gestational hypertension compared with normotensive pregnancy suggests that MMP-9 plays a role in the pathophysiology of gestational hypertension. The aim of this study was to provide an objective measure of the suppression of irrelevant information (in a conjoined selective visual attention task) under conditions that were perfectly comparable from the viewpoint of the motoric processes involved. In addition, a discrete pericellular capsule composed of fine, faintly banded fibrils is described which surrounds and encloses the pericellular matrix and chondrocytes of the middle and deep layers but not of the superficial layer. An on-grid method for the specific demonstration of glycogen in electron microscopy. Prospective studies will be required to estimate the potential benefits of estrogen suppression therapies for the prevention and adjuvant treatment of BRCA1/BRCA2-related breast carcinomas.

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We found that UV-C light irradiation induced marked cell death tested by 3-(4,5-Dimethylthiazole-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and TdT-mediated biotin-dUTP nicked-end labeling (TUNEL) assay. Expression of five viral antigens in cells infected with wild-type and SSPE strains of measles virus: correlation with cytopathic effects and productivity of infections. First, the PI neurons appeared to convey only a subset of the modulations found in the SC: they exhibited saccadic suppression, the inhibition of activity at the time of the saccade, but did not clearly show the attentional enhancement of the visual response seen in SC. We found that RAR binding throughout the genome is highly coincident with estrogen receptor alpha (ERalpha) binding, resulting in a widespread crosstalk of RA and estrogen signaling to antagonistically regulate breast cancer-associated genes. Carotid artery in-stent restenosis in a patient with contralateral total occlusion, resolved with drug-eluting stenting.

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Commissioning and clinical implementation of a sliding gantry CT scanner installed in an existing treatment room and early clinical experience for precise tumor localization. Type II diabetes: toward improved understanding and rational therapy. In the absence of findings that correlate with malignancy, natural history is unknown. In this study, we examined methylation frequencies and patterns using 14 marker genes in 31 proximal and 43 distal colorectal cancers.

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Reports of female urethral injuries are scarce, however, and subsequently the management is not standardized. Carcinoma of the cervix: treatment with continuous intravenous bleomycin.

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A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing. Sedentary nematodes are destructive plant pathogens that cause significant yield losses. We also determined whether protein levels in the lungs of NNK-treated mice could be further modulated by the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate (p-XSC). Trends in GME suggest that the primary care medical workforce of the future will include more women, more IMGs, and more DOs.

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The reaction conditions are simple, and only transition-metal catalysts and ligands are essential. Heterogeneity of macrophages and dendritic cells as accessory cells. Carbon isotope fractionation by aerobic heterotrophic microorganisms An analysis of the release data demonstrated that for this series of drugs, drug partition coefficient has the largest effect on release rate, with molecular weight exhibiting a smaller effect.

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Conditioning stimulation of the DR also produced an inhibition of the spikes elicited by stimulation of the optic tract and visual cortex of at least three-quarters of the TRN neurons. We investigated gallbladder function in 10 young women on two occasions: first during the follicular phase of the menstrual cycle, when endogenous progesterone is low, and again after the ingestion of medroxyprogesterone acetate, 10 mg/day for 10 days, just prior to the next menstrual period. Indiana pouch stone formation caused by a long-forgotten metallic ball bearing. Finally, the identification of a pharmacologic approach to suppress EphA2 expression and signaling highlights the attractive possibility that Hsp90 inhibitors may have clinical utility in antagonizing EphA2-dependent tumorigenic progression.

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Converting enzyme inhibition during chronic angiotensin II infusion in rats: evidence against a non-angiotensin mechanism. Although such compositions occur in later periods of Earth history (for example, the Cretaceous komatiites of Gorgona Island), the more recent examples tend to have lower MgO content than their Archaean equivalents. Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic review. The skills learned from creating an answerable question and searching the evidence, as outlined in this article, provide a solid basis for life-long learning and improved patient care. In some instances, these risk factors are likely to interact, whereby their joint effects convey a level of risk that is either significantly more or less than the sum of these risks.

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Evidence for intracellular localization of alpha-fetoprotein in the developing rat brain. The analysis of the acetabular defects was done preoperatively according to the AAOS classification.

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A broad-based panel with topic expertise evaluated the available evidence based on a structured literature review using a Medline search from 1966 until November 2004. Treatment of adenovirus hepatitis with cidofovir in a pediatric liver transplant recipient. Serum samples were collected from 142 patients over 16 years of age with newly diagnosed inflammatory joint disease. Although feline salivary glands have been used in investigations on secretion and microlithiasis and both processes involved calcium, nothing is known about its distribution in these glands. Spacers versus nebulizers in treatment of acute asthma - a prospective randomized study in preschool children.

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So far, the molecular mechanism of such proton pumping driven by electron transfer has not been determined in any biological system. Severe atrial structural remodeling may reflect irreversible damage of the atrial tissue in patients with atrial fibrillation (AF) and is associated with changes of P-wave duration and morphology. Some nnAbs also bound bystander cells that may have captured viral proteins. Antibodies against UL122 and US28 induced the expression of genes encoding for adhesion molecules, chemokines, growth factors and molecules involved in the apoptotis process together with other genes known to be involved in the initiation and progression of the atherosclerotic process. To test the capabilities of the technique we periodically imaged the retinas of the same rats for four weeks.

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The cmc of SDS and the amount of SDS bound to the chitosan at saturation were largely independent of the holding temperature (10-40 degrees C). The implemental deviation is reduced when measurements are conducted using a sufficiently cooled CCD detector at a constant room temperature. Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone. Quantitative ETCO(2) may be an objective, noninvasive, and effort-independent way to assess the severity of asthma. This occurs in local tissues and lymph, with the remainder being cleared by the sinusoidal liver endothelium upon entering the vascular compartment.

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Insights into atherosclerosis therapy in antiphospholipid syndrome. An etiologic role for rate of blood glucose correction or speed of hydration was not substantiated by this experience and review.

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This research was performed to investigate the relationship between 16 candidate genes responsible for dopaminergic transmission or iron metabolism and familial restless legs syndrome. Two (2) patients at the 66.23-MBq/kg (1.79 mCi/kg) dose level had both grade 3 thrombocytopenia and grade 3 neutropenia that persisted for at least 2 weeks but were reversible. It is found that, at lower temperatures, higher loadings are more stable, whereas at higher temperatures, lower loadings are more stable. Simple approach to the radiated scalp wound using INTEGRA skin substitute. The other two aborted cloned fetuses have similar methylation levels to those of aborted AI fetuses.

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Levels of E2 to A (representative of aromatase activity) in FF were examined in relation to the volume of FF. Tumour samples embedded in paraffin were tested, and the minimum duration of follow up was five years or to death. Immunostaining micrographs showed that ECs cultured on gelatin-grafted PCL NF were able to maintain the expression of three characteristic markers: platelet-endothelial cell adhesion molecule 1 (PECAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1). Pulmonary and systemic vascular responses to vasoactive agents after chemical sympathectomy.

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Complete blood counts (CBC) have been recognized as an easy and readily available screen for hematotoxicity following occupational exposure to 1,3-butadiene. SRS microscopy has been effectively employed in the study of fat metabolism, helping uncover novel regulators of lipid storage. Sexual segregation of seasonal foraging habitats in a non-migratory marine mammal. The long form predominates in most brain regions (except the cerebellum) while the short form predominates in peripheral tissues.

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Since these cells also form Schwann cell myelin that is arguably likely to be resistant to MS pathology, they share some of the main advantages of Schwann cells without suffering from the disadvantages that render Schwann cells less than ideal candidates for transplantation into MS lesions. The model is motivated by the biology of the major vectors of malaria in Africa. This comparison was performed for both glucose-grown/ammonium-limited and ethanol-limited/ammonium-excess chemostat cultures. Methodological considerations in cost of prostate cancer studies: a systematic review. Enhancement of flavivirus infection in vitro in the presence of subneutralizing concentrations of homologous or heterologous antiserum has been well described.

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Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress. Food animals, especially poultry, are reservoirs of the organism and infection occurs following consumption of untreated surface water, unpasteurized milk, incompletely cooked meat or other contaminated food products. Specificity of synthetic polyribonucleotides hydrolysis by endoribonuclease from cobra (Naja oxiana) venom

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Although hypothalamic hamartomas should always be ruled out in patients with gelastic epilepsy, laughing seizures can also arise from frontal and temporal lobe foci, which can be surgically removed. Carboxymethylated cyclodextrins and their complexes with Pr(III) and Yb(III) as water-soluble chiral NMR solvating agents for cationic compounds. Autoantibodies to band 3 during aging and disease and aging interventions.

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Purple Sweet Potato Attenuate Weight Gain in High Fat Diet Induced Obese Mice. Immunohistochemical localization of prostate-specific markers within the accessory male sex glands of Cowper, Littre, and Morgagni. Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs. This study was aimed at assessing the prevalence and associated factors of DKA in children with newly diagnosed T1D in Addis Ababa. Small molecules such as mannitol probably pass through numerous cellular pores with a maximum radius lying between 0.40 and 0.54 nm and absorption is closely related to mucosal surface area.

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No specific echo pattern allowing differentiation between benign and malignant tumors was found. Strain FukuSWIS1, Obtained from Acidic Lake Grosse Fuchskuhle, Indicates Photoheterotrophy and a Potential for Humic Matter Degradation.

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Here, we formalize a general framework for feature extraction, based on Partial Least Squares, in which one can select a user-defined criterion to compute projection directions. Within schizophrenia participants, DLPFC activity during cognitive control of emotional information predicted changes in positive and negative mood on days following highly distressing interpersonal conflicts. We observed that the movement of centrioles at the time of cytokinesis was impaired in the irradiated, bridged cells. We postulate that unreduced gametes play a major role in the evolutionary success of dogrose hybrids because they provide highly homologous chromosomes crucial for bivalent formation during canina meiosis and thus ensuring this unique form of sexual reproduction.