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Factor VIII procoagulant activity (VIII:C) and factor VIII-related antigen (VIIIR:AG) were normal, but both patients revealed an increased ristocetin-induced platelet aggregation and a qualitative abnormality of the factor VIII protein, which was characterized by fast electrophoretic mobility of VIIIR:AG and an abnormal elution of factor VIII-related activities on Sepharose 2B. The use of CSF t-PrP levels may be beneficial in clinical practice in addition to the current classic biomarkers.

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Intestinal failure is a condition characterized by malnutrition and/or dehydration as a result of the inadequate digestion and absorption of nutrients. Marine n-3 polyunsaturated fatty acids have beneficial effects on the prevention of type 2 diabetes in Asian populations.

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The aim of this study is to investigate the effect of menadione, an activator of MAPK pathway, on gastric acid secretion and experimentally induced gastric ulcer in rats. Neuronal injury from ischemic stroke is aggravated by invading peripheral immune cells. Reduced concentrations of the first component of complement in hypotammaglobulinemia: correction of infusion of gamma-globulin.

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Some challenges are: At what age is a minor able to decide about his health? The role of follicle stimulating hormone in testicular function of the mature rhesus monkey. Ever-increasing utilization of the web browsers, laptops and handheld devices, as opposed to desktop applications and static organizational computers, lead to development of different web technologies.

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Retinal progenitor cells of adult rat are also present in optic nerve and in a few ciliary processes. Incidence and risk factors of ventricular fibrillation before primary angioplasty in patients with first ST-elevation myocardial infarction: a nationwide study in Denmark. Chloroplasts are the defining organelle of photoautotrophic plant cells. Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1.

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5,8,11,14-eicosatetraynoic acid (ETYA), a widely used inhibitor of cyclooxygenase and lipoxygenase, inhibited the incorporation of 14C-arachidonic acid into cell lipids of the murine thymoma EL4 whereas oleic acid had no effect. The linker-insertion mutants were useful for mapping MAb AP7, a previously ungrouped neutralizing MAb, and provided further information concerning other discontinuous epitopes. Effect of mineral content on the nanoindentation properties and nanoscale deformation mechanisms of bovine tibial cortical bone. The data obtained suggest that the decreased sensitivity of granulosa cells to somatotropin at the terminal stages of maturation of the antral follicles is essential for their development and acquisition of the ability for ovulation. Our study provides evidence for an essential function of neuronal Gal, within a specific hypothalamic area, in stimulating the behavioral process of fat ingestion and body weight gain.

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We report the computed tomography (CT) and magnetic resonance imaging (MRI) findings of a rare case of synovial sarcoma of the sternum in an 86-year-old man. Puromycin aminonucleoside (PAN)-induced glomerular injury in rats mimics minimal-change nephrotic syndrome (NS) in humans. Stressful life events, depression, and anxiety symptoms were measured twice five years apart. Demographic data, comorbidities and infecting organisms were recorded.

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Shaken baby syndrome is a significant cause of infant morbidity and mortality and is widely recognized in the medical literature. Intrauterine, intraperitoneal transfusion is associated with a poor survival rate in fetuses with hydrops and low gestational age. Reduction in sudden deaths by a multifactorial intervention programme after acute myocardial infarction. mansoni infection was studied in two strains of mice genetically selected, over 18 generations of assortative mating, for extreme phenotypes of susceptibility (TS) and resistance (TR) to immunological tolerance. In Fabry disease and Gaucher disease, GSL storage diseases, the excess glycolipid in plasma is distributed among the various lipoprotein fractions in the same relative proportions as in healthy individuals.

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Uncultivated unicellular N(2)-fixing cyanobacteria (UCYN-A) lack major metabolic pathways including the tricarboxylic acid cycle and oxygen-evolving photosystem II. Further studies on the smooth-surfaced membranes isolated from rat brain. Human placental indanol dehydrogenase: some properties of the microsomal enzyme. In a series of prospective randomized trials conducted in the Surgery Branch of the NCI in conjunction with the Radiation Oncology and Medical Oncology Branches of the NCI, it appears that adjuvant chemotherapy with doxorubicin and cyclophosphamide is of major benefit in improving disease-free and overall survival in patients with high-grade soft tissue sarcomas of the extremities.

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Furthermore, the decrease in promoter activity induced by expression of E2F-1 and Rb was reversed by trichostatin A treatment of Saos-2 cells. FCL evolution in individuals showed that FCL can predict rejection days before histopathological diagnosis. Quasi-epitaxial Metal-Halide Perovskite Ligand Shells on PbS Nanocrystals. 10(-6) M) of the corresponding amidine-containing Schiff base chelates with regard to bovine trypsin.

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In the latter populations, although there are no known land barriers, the bifurcating South Equatorial Current at the north-eastern horn of Brazil can be a potential barrier to gene flow and may promote the genetic differentiation of these populations. Although the figures presented are not conclusive since they are derived from calculations rather than an actual test, the results are encouraging enough to warrant serious testing in Third World villages.

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Perioperative Mortality and Long-Term Survival in 80 Dogs and 32 Cats Undergoing Excision of Thymic Epithelial Tumors. This approach can be extended to other receptor systems and can improve the selection of clinical candidate compounds by potentially dialing-out harmful off-target effects or dialing-in beneficial off-target effects in a quantitative and controlled way. Deficits of this sort are not apparent after treatment with a 2-week course of repetitive transcranial magnetic stimulation. Recent data from rats, mice and birds show that accelerated postnatal growth is a trigger for the development of adult disease and, ultimately, can affect longevity. Previous studies demonstrated the role of bacterioferritin and MrgA in iron storage.

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Positive expression of lens epithelial cell MnSOD mRNA was determined by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR), and its levels were monitored by real-time PCR up to 24 h after 17beta-E(2) administration. To compare the natural history of weight change from mid to late life in men with and without dementia in late life. Resection of the primary tumor and supraomohyoid neck dissection, with or without postoperative radiotherapy. Implementation, construct validity, and benefit of a proficiency-based knot-tying and suturing curriculum.

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Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway. The numerical density of vessels was determined in the gray and white matter, and their staining intensity was rated using a three-point scale. Out of 105 cases of myeloma admitted to this Department, 6 cases of spinal cord compression were observed, with a favourable outcome after treatment by laminectomy combined with radiotherapy.

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Comparison of the inhibition by methylmercury and triethyllead of galactolipid accumulation in rat brain. Using genome-wide DNA binding location analysis integrated with gene expression and cell physiological data, we demonstrate that a bacterial-type transcription factor (TF), called RosR, and five TFIIB proteins, homologs of eukaryotic TFs, combinatorially regulate over 100 target genes important for the response to extremely high levels of peroxide. To introduce the use of a portfolio (PF) as a learning and evaluation tool for hospital medical students in a urology department. Inflammation is a key factor in the progressive loss of lean tissue and impaired immune function observed in ageing. ALL can be used as a reference measurement to quantify annular dilatation and papillary muscle separation in patients with FMR.

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A prospective before/after trial in which rates of IVD-associated BSI are determined during a period of active surveillance without process control (phase 1) were compared with rates of IVD-associated BSI after implementing an infection control program applying process control (phase 2). To evaluate population-based rates of Respiratory Syncytial Virus (RSV)-associated infant hospitalizations related to race/ethnicity, payer source, and geography in California. However, phobic anxiety and hostility scales were associated with abstinence for MA-dependent residents but not for those dependent on other substances. Chest infection associated with the Waterhouse-Friderichsen syndrome. The EMG activity integral of the rectus femoris muscle was chosen as quantitative parameter for degree and change of muscle tone.

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Simultaneous determination of caffeine, 8-chlorotheophylline, and chlorphenoxamine hydrochloride in ternary mixtures by ratio-spectra zero-crossing first-derivative spectrophotometric and chemometric methods. This was a one-arm prospective cohort study whereby 89 pregnant women with uncomplicated Plasmodium falciparum malaria receiving artemether-lumefantrine (ALu) participated in pharmacokinetics and pharmacodynamics study. The crystal structure of ASA suggests that the (alpha(2))-(alpha(2))(4) equilibrium is regulated by protonation/deprotonation of Glu-424 located at the interface between (alpha(2)) dimers in the octamer.

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Perturbation to microbiomes brings about undesirable phenotypes in the hosts, resulting in diseases and disorders, and disturbs the balance of the associated ecosystems. Together, with the famous aviator and engineer Charles Lindbergh, they were the first scientists capable of keeping an entire organ alive outside of the body, using a perfusion machine. In the ultracentrifuge PEG-phenylalanine ammonia-lyase exhibits a lower sedimentation rate than the unmodified enzyme, despite the fact that it is much larger.

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Therefore, in this study, we investigated whether or not a newly developed minodronate, YM529, could prevent osteolytic bone metastasis of human TCC and also enhance the effect of docetaxel in a bone tumor model of athymic nude mice. To analyze functional and morphologic alterations that occur at the mitochondrial level by flow cytometry and laser scanning confocal microscopy (CLSM) combined with factor analysis of biomedical image sequences (FAMIS).

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However this occurred to a lesser degree than in young rats treated with HEALOS. Furthermore, we show that the SKR-1(M140I) weak loss-of-function mutation interferes with SKR-1/SEL-10 binding. Evaluation of six tumor markers in patients with carcinoma of unknown primary. The commonly used analytical approximation assumes that errors are relatively small. We carried out numerical simulations of a neural network model for a lateral belt area of auditory cortex.

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On the Oxidation State of Manganese Ions in Li-Ion Battery Electrolyte Solutions. In the context of cardiovascular health, a particular group of flavonoids, namely, the flavan-3-ols (flavanols), has received attention. Patient safety studies have identified older adults as a high-risk group for adverse events (AEs).

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Surgical skills increasingly are taught in training laboratories outside the operating room. In the present study, we investigated whether the effects of a novel, double-stranded, recombinant adeno-associated virus vector (rAAV)-mediated antisense angiotensin II receptor 1 (AT1R) gene efficiently prevents the development of hypertension induced by a high-salt diet in adult, male Sprague-Dawley (SD) rats. Also, both isoforms degraded myelin basic protein, the major protein component of nervous tissue, but were inefficient against hemoglobin, thus supporting the adaptation of T. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

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Colon cancer is less common, there is more evidence that screening is effective, and the relatively high risk of dying from this disease in asbestos workers makes screening useful. Effect of intramuscular application of selected neuropeptides on morphology of muscle. Fully human anti-BAFF inhibitory monoclonal antibody tabalumab does not adversely affect T-dependent antibody responses in cynomolgus monkey (Macaca fasicularis): A summary of three pre-clinical immunotoxicology evaluations. The synchrony of these tempos of molecular change supports the notion that rapid genetic evolution accompanied periods of major adaptive radiations.

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Sixty-two families that included parents with panic disorder and children who underwent laboratory-based behavioral observations were studied. Screening, cloning and overexpression of Aspergillus niger phytase (phyA) in Pichia pastoris with favourable characteristics. Computed tomography showed hypodense areas in the territory of the right middle cerebral artery, indicating acute cerebral infarct.

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Clinical Policy for the Initial Approach to Patients Presenting With Acute Blunt Trauma. Furthermore, many interferon-inducible genes were also up-regulated by the treatment.

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TUNEL and flow cytometry were used to assess the effect of Bax on apoptosis. Dwelling, house and home: towards a home-led perspective on dementia care. Genetically engineered mice alter gene function by over-expressing, eliminating, or modifying a gene product. Laboratory studies in humans and animals have shown that particulate toxic pollutants-particularly diesel exhaust particulates-can enhance allergic inflammation and can induce allergic immune responses. We present a case of long-term survival in a patient that involved intrahepatic cholangiocarcinoma that metastasized to the paraaortic lymph nodes.

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Tuberculous infection and pulmonary tuberculosis in Trivandrum and in Oslo in present days. Many superficial cells in the area were in various stages of necrosis.

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Skeletal myoblasts, even if they are not able to differentiate in cardiomyocytes, can improve cardiac contractility at the level of the fibrous scare which substitutes the necrotic area. The objective was to assess effectiveness of CR across sectors coordinated by a nurse case manager (NCM). Our findings also demonstrate that Nodal-expressing ES cells might be a source of highly active proteins that could be used for developing endoderm or mesoderm tissues in regenerative medicine. Source of work area reduction following hemiparetic stroke and preliminary intervention using the ACT3D system. In a prospective, multicenter, open-label, parallel-group study we determined the concentration of moxifloxacin in plasma and uterine tissue after a single, 400-mg intravenous dose of moxifloxacin.

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There seems to be a relation between the property to be incorporated into melanin and the tyrostatic activity. Implementation of physicochemical and sensory analysis in conjunction with multivariate analysis towards assessing olive oil authentication/adulteration.

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Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart. In this work, through a series of computational studies, a common binding site of oryzalin, trifluralin, and GB-II-5 on apicomplexan and kinetoplastid alpha-tubulin is proposed. The compromised patient who presents to the emergency department with pulmonary complaints is becoming a common occurrence. Their longitudinal surface plasmon resonance can be tuned, providing a strong near-infrared (NIR) extinction coefficient peak within the tissue transparency window. We therefore assembled a new fatigue scale from a set of widely used scales and assessed its psychometric properties in a large sample of MS patients.

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CINAHL, MEDLINE, Psychology and Behavioral Sciences Collection, Sociological Collection, and PubMed. Alterations of collagen XVII expression during transformation of oral epithelium to dysplasia and carcinoma. The model also shows how much the analyte-antibody binding constant and the surface density of the capture antibodies influence the performance of the assay. Using a small pilot study, VISTA was shown to produce diagnostic quality images at acceleration rates up to 15.

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Comparison of the scores on the function-related tests between patients and controls was evaluated. HPV-16,18 DNA was examined in 112 tumor specimens using fluorescence quantitative PCR. Recently, gene expression profiling studies in AML showed a remarkable level of concordance in findings, which may ultimately lead to an increasingly refined molecular taxonomy. To analyze the secretory mechanism of immunoglobulins into pancreatic secretion, pancreatic juice IgA was measured by single radial immunodiffusion and characterized immunochemically, and immunoglobulins, J chain and secretory component (SC) were localized immunocytochemically in pancreatic tissues by the peroxidase-labeled antibody method. The similarity of image content is also incorporated into point matching in order to improve image matching.

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Here we provide a detailed description of the post-mortem findings of the hearts of three children with Costello syndrome. We explicated the early outcomes of 7 consecutive adolescents, where single port video-assisted thoracoscopic sympathectomy was performed for primary palmar hyperhidrosis. Computer assisted analysis was repeated at every control and performed at the same levels within the reconstruction, so that subsequent CT exams could be compared.