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This review discusses a checkpoint activation model in which chromatin perturbations lead to the conversion of inactive ATM domains to phosphorylated, active ATM monomers. We propose that this stress-induced toxicity may have a role in pathogen defence. The teratogenic role of two short-chain unsaturated fatty acids, octinoic acid and undecylenic acid on the hemimetabolic metamorphosis of the insect Rhodnius prolixus (Hemipter) is studied. Three hundred seventy-five Gram-negative bacterial strains were isolated from urine specimens of as many patients affected by symptomatic or asymptomatic urinary tract infections.

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We summarize here the SNAREs that interact with CFTR and discuss the roles of these SNAREs in the intracellular trafficking of CFTR and CFTR-associated pathophysiology. Glycerol phosphate dehydrogenase: reduced activity in multiple sclerosis plaques confirms localization in oligodendrocytes.

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To better understand the molecular mechanism by which cell proliferation and differentiation are regulated by progesterone and MPA in human breast cancer, we utilized cDNA microarray and quantitative real-time RT-PCR methods to identify their target genes. In 1983, Walsh introduced anatomical radical retropubic prostatectomy. They were located at all levels of the drmis between the collagen bundles. Several kinds of kinase inhibitors markedly increased the CYP1A1 mRNA expression. This retrospective review included 240 patients treated with radical cystectomy with or without multiagent chemotherapy at our institution between 1984 and 1990 for clinical stage T2 to T4 transitional cell carcinoma of the bladder.

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Lysosomal storage diseases can have head and neck manifestations, and bone involvement in Gaucher disease is common. Therefore it follows that none of the above-mentioned properties of K channels are strong evidence for the existence of such sites.

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The RASS demonstrated excellent interrater reliability and criterion, construct, and face validity. Incubation of anterior pituitary (AP) fragments of rats was used to determine the specific role played by vasopressin (VP) in the overall effect of crude hypothalamic median eminence (HME) extract on ACTH release.

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In contrast, whilst glial cells do not produce pro-inflammatory molecules in the presence of apoptotic neuronal death, phagocytic activity is rapidly induced. For some varicella and zoster cases, aciclovir, the original standard, is being replaced by valaciclovir and famciclovir as preferred therapies. Sequences between the IS element and the restriction site are then amplified using an IS6110 specific outward primer and an oligonucleotide specific to the ligated priming site.

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It exerts its rapid inhibitory action mostly through GABA(A) receptors, which are targets for benzodiazepines, barbiturates, neuroactive steroids and distinct anticonvulsive agents. The authors worked in a busy regional fracture unit, where it was noted that important data was being omitted from medical notes. The fine balance between low radiation dose and high image quality is considered throughout, with an emphasis on obtaining diagnostic quality imaging at the lowest achievable radiation dose. Cellular senescence and AMPK-mTOR signaling markers associated with EMT were detected.

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Prediction of non-reassuring FHR pattern with Doppler analysis of uterine and fetal arteries. But among those reporting a low frequency of positive states of mind, perceived stress was more strongly related and depression, anxiety, and perceived health suggesting a buffering effect of positive states of mind against the negative influence of stress. Furthermore, we provide evidence that developmental nurse cell PCD in late oogenesis shows hallmarks of necrosis. In patients with primary tumors, this relapse is mainly due to clinically occult micrometastasis present in secondary organs at primary diagnosis but not detectable even with high resolution imaging procedures. Some of these functions undergo daily variations, such as temperature or water loss, suggesting the presence of time-keeping mechanisms.

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Decreased sensitivity persisted after 30 days of isolate culture. Recent advances have highlighted the role of Th2-driven cytokines in the development of EGID, and clinical studies have verified that children and adults with EGID often have positive skin testing to food allergens. We present a new generation of three-dimensional (3D) measuring systems, developed for the process of crime scene documentation.

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What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Disease-specific and overall survival were the primary outcome measures.

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Risperidone, a benzisoxazol derivative, is a novel antipsychotic agent which combines potent serotonin (5-hydroxytryptamine) 5-HT2 and dopamine D2 receptor antagonism. PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling. Neurally mediated syncope frequently has a characteristic trigger, although this may not be apparent.

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How type I IFN regulates the dermal fibroblast and its participation in the development of dermal fibrosis is not known. Furthermore, the number of small scattered ulcers of the small intestine was significantly reduced by the high dose of FK-506 (2 mg/kg), but not by cyclosporin or prednisolone.

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The goal was to find the simplest model that accounts for the heterogeneity in tissue partition coefficients and accurately describes initial distribution kinetics of thiopental in dogs. With the simple inclusion of the peptide, the DPL complex showed much enhanced transfection. Simultaneous determination of sulfonamides and fluoroquinolones residues in chicken by high performance liquid chromatography-electrospray tandem mass spectrometry The proposed model generalizes those usually quoted in the literature, taking into account the significant ionic currents, the temperature dependence of the electrical parameters, and the stochastic synaptic inputs.

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A white diabetic patient on insulin therapy presented with recurrent hypoglycemia despite very high glycosylated hemoglobin (HbA1c) values. Analytical methodology for the determination of Kepone residues in fish, shellfish, and Hi-Vol air filters. Transesophageal echocardiography in prone position during severe acute respiratory distress syndrome. Kinase activity measurement was assessed using two new sensitive procedures (Facetrade mark and CBA) requiring few cells. Possible antidiabetic and antihyperlipidaemic effect of fermented Parkia biglobosa (JACQ) extract in alloxan-induced diabetic rats.

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The sharp decline of the heritabilities at adolescence in most of the morphometric traits, and the acromio-iliac index in particular, may be due to the large inter-individual variation in the age at which the adolescent growth spurt is reached in both sexes. Reference ranges for fetal venous and atrioventricular blood flow parameters.

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Moreover, measurements of right-to-left cardiac shunts were of benefit in the management of children with cyanotic heart disease. Kainic acid-induced albumin leak across the blood-brain barrier facilitates epileptiform hyperexcitability in limbic regions.

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To investigate whether adrenomedullin influences the kinetics of bone marrow cells, and whether adrenomedullin promotes regeneration of alveoli and vasculature and thereby improves lung structure and function in elastase-induced emphysema in mice. This paper introduces a new technique for the indirect measurement of the systolic and diastolic blood pressure of an individual. Thrombin induced aggregation results in release of arachidonic acid primarily from phosphatidyl choline and phosphatidyl inositol.

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Moreover, the optical performances of the projector such as color difference and the LED alignment tolerance were also measured and discussed. Antidiabetic coumarin and cyclitol compounds from Peucedanum japonicum. We have used this methodology in combining data sources for both retrospective studies of known outbreaks and surveillance of high-profile events of concern to local public health authorities.

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These reactions were monitored by rapid unconventional direct gas chromatography-mass spectroscopy. Development of chronic active hepatitis of the autoimmune type following hepatitis B virus infection with HBSAg-persistence. The paper reports experiments on 34 subjects, where it compares the performance of the new pulse measurement method to the one we reported previously.

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Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Structural features of extraocular muscles of children with strabismus. Hypocholesterolemia is a common finding in hospitalized elderly people and is associated with increased mortality. We developed a microanalytical technique to measure beta-defensin-2 in the stratum corneum using a combination of immunoprecipitation and Western blotting. A case is described of a superficial penetrating eye injury secondary to the use of a rotating wire brush, despite the use of safety glasses conforming to British safety standards.

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Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD). Over the next eight years the drug was therefore tried in a prospective study of 20 other patients with benign familial tremor alone. Our data in Sprague-Dawley rats support the conclusion that L-arginine-induced increases in rCBF can decrease infarction volume.

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The secretion of several other lysosomal enzymes was also stimulated by caerulein. DNA methylation 40 years later: Its role in human health and disease. In these studies, fluorescence in situ hybridization with several chromosome-specific DNA probes was used to investigate the ability of the benzene metabolite hydroquinone to induce hyperdiploidy in interphase human lymphocytes. Phase I clinical trial of temsirolimus and vinorelbine in advanced solid tumors.

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Deletion of KlHAP1 increases the resistance to oxidative stress or cadmium and the induction of KlYAP1 and KlTSA1 by the addition of 0.5 mM H(2)O(2) is repressed by KlHap1p. Most chronic active hepatitis sera were reactive to two or more lamin domains and reacting SLE sera always gave positive signals to coil 2 and/or coil 1B. The in vitro microbiological tests provide evidence that MON-UR1-Na shows higher antibacterial activity against human pathogenic bacteria, including antibiotic-resistant Staphylococcus aureus and Staphylococcus epidermidis than the parent unmodified antibiotic-Monensin A.

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The course is rapid, the clinical symptoms are serious, and the prognosis is very poor. The intradialytic activation of leukocytes is a major cause of hemodialysis (HD)-associated complications. The influence of selective attention on the mnemonic binding of contextual information.

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Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus. We also describe a new polynomial-time algorithm for the case of consistency with an unknown species tree and full knowledge of pairwise orthology/paralogy relationships, as well as a branch-and-bound algorithm in the case when unknown relations are present. Brucellosis seroprevalence was strongly correlated with the timing of the feeding season. Fertility-sparing surgery for young women with early-stage cervical cancer.

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The IC50 value of Y1-JZTX-V on TTX-R sodium currents was 5.8 times as many as that of natural JZTX-V. The Function and Organization of the Motor System Controlling Flight Maneuvers in Flies. The premanufactured GaBP ring system can be used in the banded gastric bypass operation instead of a surgeon-fashioned ring or band in current use. Mining the probiotic genome: advanced strategies, enhanced benefits, perceived obstacles.

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Cytoplasmic and nuclear inclusions underwent extensive morphogenesis through 96 to 120 hours postinfection. The guide systems for percutaneous puncture include: palpation, mammography-stereotaxy, ultrasound and magnetic resonance. In the case of missions to areas at high epidemiological risk such as Afghanistan and Iraq, substantially enlarged laboratory screening is conducted with an emphasis on serodiagnosis of infectious diseases.

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Towards this, we present a theoretical model that replicates observed interaction outcomes between fungal colonies. Postsynaptic glutamatergic neurons can use retrograde signaling to control their presynaptic inputs and these results suggest vGluTs could play a role in regulating retrograde signaling in the CN under different conditions of excitatory input.

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Expression of ataxin-2 with expanded repeats in PC12 and COS1 cells increased cell death compared with normal ataxin-2 and elevated the levels of activated caspase-3 and TUNEL-positive cells. The charged linker region is an important regulator of Hsp90 function. The sustained expression observed throughout the cell cycle suggests that the growth-related function of c-myc may be required during the G0-G1 transition and in all phases of the cycle of the growing cell. Blood urea and creatinine concentrations were measured in 47 cases but not all the rabbits had high levels of both. Intra-pair comparison showed the co-existence of shared as well as distinct epitopes in six of eight pairs and a complete absence of concordant epitope recognition within two other pairs.

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However, there are currently few tools available with sufficient spatial or temporal resolution ideal for all experimental studies. GBL also induced a three-fold greater increase of brain dopamine levels in LS than in SS mice. Longer-term effects may manifest as reduction in regional brain volumes since brain areas with the highest energy demand will be most affected by a restricted energy supply and may be reduced in size.

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MPM-2 treatment of midpieces prior to injection blocks their ability to form asters in oocytes activated by calcium stimulation. However, as biochemical assays based on immobilized protein arrays progress from immunoassays to more delicate functional assays, the demand for methods of miniaturized, gentle, and oriented immobilization, which are applicable to many different target proteins, becomes larger.

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Calreticulin is involved in ischemic postconditioning-induced attenuation of ischemia/reperfusion injury in rat skeletal muscle A recurrence of seizures was observed in 25 of 91 patients with a Pocket Monster seizure. Loss-of-function mutations either in the EPM2A or in the NHLRC1 gene lead to polyglucosan formation. Our field manipulations revealed that mortality among successive cohorts of young fishes was density dependent at each reef, but that its strength varied by approximately 1.5 orders of magnitude. In any case, when reporting the treatments, absorbed dose and irradiation conditions should always be specified in addition to the weighting factor and the weighted dose.