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Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Dutasteride. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. The FDA approved Dutasteride in November 2001. Dutasteride is used for the treatment of benign prostatic hyperplasia. It improves symptoms of enlarged prostate, reduces retaining of urine, and reduces the risk of the need for prostate surgery.

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In 40 paraffin-embedded CRC samples, each for non-LNM CRC and LNM CRC, four differentially expressed proteins identified by proteomics analysis were detected by tissue microarray with immunohistochemistry staining to access the clinicopathological characteristics of these proteins in LNM of CRC. IER5 promotes irradiation- and cisplatin-induced apoptosis in human hepatocellular carcinoma cells. Exophthalmometric values did not increase in any of the patients and in 2 cases of edematous exophthalmos the protrusion and edema disappeared after this treatment. The control group consisted of 20 RT-naive patients with primary brain tumors. It is not observed with the new PBS method which has yielded highly reproducible results.

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Use of CobraPLA for airway management in a neonate with Desbuquois syndrome. This approach aims to provide arguments for discussion about the impact on clinical results of any condition able to significantly alter dosimetric or ballistic related data. The bioactivity of the p160 peptide (VPWMEPAYQRFL) was evaluated in vitro and in vivo.

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Biosynthetic studies have shown that the receptor undergoes several post-translational modifications including the processing of its asparagine-linked oligosaccharides, phosphorylation of serine residues, and unknown modifications required for acquisition of immunoreactivity and functional activity. Mobility of apolar lipids of reconstituted low density lipoprotein as monitored by electron spin resonance spectroscopy. Overall, this study demonstrates that actin polymerization driven by the complex multicomponent signaling cascade of the Golgi apparatus can be reproduced with a biomimetic system.

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Positive staining with keratin antiserum suggests the epithelial origin of CB but the importance of fibrin and IgM staining remains unknown. GFR was measured as plasma clearance of iohexol or (51)Cr-ethylenediaminetetraacetic acid. Ketamine increases blood pressure and heart rate by unknown mechanisms, but studies suggest that an intact central nervous system and arterial baroreceptors are required. Thus, the gamma complex uses ATP binding and hydrolysis as a mechanism for modulating its interaction with DNA in which the ATP-bound form binds with high affinity to DNA but elongation-proficient DNA substrates preferentially trigger hydrolysis of ATP and conversion to a low affinity state. Collectively, we demonstrate that vaccination with CJ9-gD elicits strong and protective immune responses against primary HSV-1 skin disease and reduces the extent of latent infection by challenge virus.

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The mean patient age at presentation was 38 years (range 23-59 years). Re: Acute kidney injury in major gynaecological surgery: an observational study. Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.

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It was shown: 1) that the clearance of bleomycin from the blood is markedly retarded in severe renal dysfunction, 2) that clearance of bleomycin varies with creatinine clearance, 3) that bleomycin is probably not dialyzable, 4) that determinations on serum and plasma were equivalent, and 5) that the radioimmunoassay and microbiologic assays gave equivalent results (P less than 0.001). Detection of the West Nile Virus and its genetic typing in ixodid ticks (Parasitiformes: Ixodidae) in Tomsk City and its suburbs In this pilot study, expression of CCK-Rs in the epithelial cells is noted in children with CAGD compared with controls.

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Medical Preparedness: Information Regarding the Correlated Activities of the Council of National Defense and the Advisory Commission, the Medical Departments of Government and the Committee of American Physicians for Medical Prepardedness. The inflammation observed microscopically correlated with marked increases in serum amyloid A and C-reactive protein. ARM81 - characterization of their genomes, proteomes and DNA methyltransferases.

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Synchronized cells were treated with 1,25(OH)(2)Vitamin D(3) over 96 h. Dentists recognize the importance of saliva in maintaining oral health and often are familiar with the clinical effects an insufficient salivary flow can have on oral tissues. However, in order to assess the potential clinical value of these new therapies, it is important not only to study the results of various clinical trials, but also to analyze the methodology and design of the trials themselves. A cohort of 29,871 Seventh-day Adventist church members in California was followed for 12 years.

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These results suggest that intersubunit interaction domains and recognition mechanisms that dictate formation of the highly specific quaternary structure assumed by this protein are common for different species of ferritins. Additive differentials in mortality rates remained stable, but since mortality declined exponentially, by a factor of about one third, proportional differentials in mortality and thus additive differentials in life expectancy have widened. In the present study, the N-acyloxymethylation approach to improve the aqueous solubility of Lu 28-179 a tertiary amine exhibiting an intrinsic solubility in the nanomolar range, have been investigated.

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By detecting these amplified DNA fragments, the feasibility of efficiently detecting metastatic cells present in chick embryo was demonstrated in vivo. To evaluate late dysphagia after chemoradiotherapy for locally advanced head-and-neck squamous cell carcinoma, and to examine its correlation with clinical and dosimetric parameters.

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Contamination during the staining process of cytological cervixuterine smears Sheng mai san, a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke in the rat.

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Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro. Brain magnetic resonance image showed acute bilateral middle cerebellar peduncle infarction. The chromophore was localized in the cell wall of these streptococcal strains and appeared to be resistant to trypsin treatment. To identify the role of DNase gamma in apoptotic foci of HNL paraffin embedded tissue sections of HNL and lymphadenopathy with hyperplastic germinal centers and paracortex in the neck lymph nodes were immunohistochemically stained for DNase gamma and the results compared with the reactivity of TdT-mediated dUTP nick end labeling (TUNEL).

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A cross-sectional, comparative study design was used for the study, with data collected using a structured questionnaire and guided observation of doctors and nurses involved in the management of patients that had caesarean sections in two comparable tertiary hospitals in Port Harcourt-the University of Port Harcourt Teaching Hospital (UPTH) and the Braithwaite Memorial Specialist Hospital (BMSH). Pure collagenase (clostridiopeptidase A, EC having a molecular weight of 70 000 was obtained from the culture medium of Clostridium histolyticym by a combination of ultrafiltrations, molecular sieve, affinity and hydrophobic chromatography. A 10 years old child was brought to the Emergency Department of Combined Military Hospital (CMH), Lahore with a history of trivial injury due to fall from a bicycle. Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study.

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The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ distribution was not affected by particle size or animal sex. In the absence of available cadaver allografts, sheet porcine xenograft is a satisfactory substitute for use on granulating wounds to diminish evaporative water loss, while amnion and meshed porcine are less effective. Synthesis and pharmacological screening for muscle relaxant, anticonvulsant, and sedative activities of certain organic compounds produced by Michael addition. The disorders of perceived auditory lateralization after unilateral damage of the cerebral hemispheres were investigated by dichotic presentation of pure tones, lateralization being obtained by interaural intensity differences.

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In contrast to the dynamics of GFP-actin, recovery of GFP-alpha-actinin fluorescence was not polarized, with the actin cross-linking protein exchanging all the length of the EPEC/EHEC induced pedestals. A defect of Kap104 alleviates the requirement of mitotic exit network gene functions in Saccharomyces cerevisiae.

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It is a cost-effective, labor-saving and time-tested system with 40 years of experience. The intermeniscal ligament was involved in the fracture in 29 cases, and the anterior part of the medial meniscus was involved in 3 cases, requiring a temporary shift before reduction of the fragment.

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At the electron microscopic level, in WT mice of both sexes, type 1 PRL cells exhibited a well-developed Golgi apparatus and a large number of strongly stained large mature and immature secretory granules. This type of cavity structure may be useful for producing controllable coherent synchrotron radiation by microbunching the particle beam. Baseline calcium and parathyroid hormone were normal within expected ranges 8-12 years after radioiodine.

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In addition, glutamatergic NMDA and AMPA receptors are important for mediating these impairments in micturition reflex. Agar diffusion studies with an antiserum to purified porcine relaxin showed a continuous precipitin line with no spurring between the two bovine relaxin fractions and NIHR-P1 porcine relaxin standard. Evidence-based assessment of pediatric bipolar disorder, part I: base rate and family history. A modern industrial route for the manufacture of methyl methacrylate involves the reaction of methyl propanoate and formaldehyde over a silica-supported Cs catalyst.

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There existed significant difference in gene expression profiles of ovarian granulosa cells between the treatment group and the control group. Furthermore, the paper discussed the growth law of the capillaries in the porous silk fibroin films (PSFF) in order to provide a theoretical basis for the designing and making of the new biomaterial of the PSFF more suitable for the growth of the cells and capillaries. Radiologically, this technique resulted in a transverse or short oblique bicortical fracture in the middle of the tibial diaphysis. The pre-specified outcomes were death prior to hospital discharge, long-term neurodevelopment, incidence of invasive fungal infection, emergence of antifungal resistance, and adverse drug reactions. Expression profiles of the genes encoding MAPK, NOS1, NOS3, and PIK3CA were analyzed, by RT-PCR, in specimens from patients with and without a history of RT to the head and neck.

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Osteoporosis, a metabolic disease, and periodontal disease, which is infectious, are both major health problems with multifactorial etiologies. After complete resection of liver metastases, patients randomised to the vaccination group received six doses of Newcastle disease virus (NDV) infected autologous tumour cell vaccine (ATV-NDV). Parallel attempts to obtain fusions of lac to bioH were unsuccessful, indicating lack of direct biotin control at the bioH locus. The best diagnostic modality remains the history and physical exam, as the area is readily accessible. Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

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Medicinal plants used for liver diseases in some parts of Kamrup district of Assam, a North Eastern State of India. For the research, mathematical modeling of embryogenesis and morphogenesis using finite elements method will open new ways for biomecanics and a dynamic quantification approach. This article explores the meaning and importance of career exploration and career development in the context of integrated treatment for young adults with early psychosis and substance use disorders (i.e., co-occurring disorders). MS-275 increased Annexin V membrane translocation and induced G1 arrest.

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Effectiveness of antiretroviral therapy in HIV-1 infected children. Loss or overexpression of ATF4 confirmed its role in CA9 induction during hypoxia. Prescribing practices and knowledge of tricyclic antidepressants among physicians caring for children. The economic burden, particularly indirect costs, was highest among those with severe pain and higher than previously reported in studies of specific NeP conditions. There are currently 2 major trials, PARTNER II and SURTAVI, that are both evaluating the role of transcatheter aortic valve replacement in intermediate-risk patient cohorts.

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Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. The China made SES were not associated with an increased risk of in-stent thrombosis but significantly reduced restenosis rate and MACE at 6 months post primary angioplasty in patients with AMI. Our findings show that the POP mixture and PFOS can have a similar effect on behaviour, yet alter the expression of genes relevant to neurological development differently. Optimal collection tubes for plasma glucose determination: confusion reigns supreme.

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17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. Therefore, in a multidimensional search space where the optimum dimension is unknown, swarm particles can seek both positional and dimensional optima. Non-invasive examinations and hemodynamic studies revealed dysfunction of the left ventricle and ostial atresia of the left coronary artery. HSF, when cocultured with sensitized lymphocytes, suppressed their MIF and proliferative responses to antigen. As life expectancies of the populations of these countries grow, the number of patients suffering from cardiac insufficiency also increases.

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Evidence of cytochrome P450-catalyzed cleavage of the ether bond of phenoxybutyrate herbicides in Rhodococcus erythropolis K2-3. The findings of thi- s study provide new insight into the mechanisms governing the regeneration of soft tissue-to-bone interfaces.

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In this series, BTO combined with quantitative CBF analysis was a safe and reliable technique for identification of patients at risk for ischemic infarction after carotid occlusion, despite a normal clinical BTO. Although the TNM stage is the most important prognostic factor for gastric cancer, there is a need for new prognostic and predictive factors, because the prognosis varies among patients of the same stage. When tested against 8 different sera from different aspergillosis patients there was a good coincidence of results. A sulfur granule produced by Pseudomonas aeruginosa in three cows was studied light- and electron-microscopically. Broad and fine-scale genetic analysis of white-tailed deer populations: estimating the relative risk of chronic wasting disease spread.

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Influences of sex and saline intake on diurnal changes in plasma melatonin and osmoregulatory hormones of Pekin ducks (Anas platyrhynchos). caverject 20 mcg injection side effect To investigate the effect of semaphorin-3F (SEMA-3F) gene transient transfection on the proliferation of Tca8113 tongue carcinoma cells. Permethrin-induced oxidative stress and toxicity and metabolism. Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line. Daily interruption of sedation (DIS) and sedation algorithms (SAs) have been shown to decrease mechanical ventilation (MV) duration.

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